en
Scientific article
Case report
English

A case of 45,X Turner syndrome with spontaneous ovulation proven by ultrasonography

Published inGynecological endocrinology, vol. 14, no. 2, p. 105-110
Publication date2000
Abstract

A well-documented case of non-mosaic Turner syndrome, with spontaneous pubertal development and ovulatory cycles is reported. Mosaicism could be excluded both by karyotyping of 172 metaphases of blood lymphocytes and fibroblasts, and by fluorescence in situ hybridization, using an X-centromeric probe, in 200 blood lymphocyte nuclei. This Turner syndrome patient underwent normal pubertal development, with spontaneous menarche at 14 years, followed by regular monthly periods. Hormonal measurements performed during puberty were consistent with the patient's pubertal development. At the age of 26 years the patient was referred for complete fertility evaluation. Detailed hormonal analyses were performed in a given cycle. They showed midluteal phase estradiol and progesterone values within the range corresponding to normal ovulation and corpus luteum function. In the same cycle, pelvic ultrasonography was also performed at days 13, 15 and 18. It demonstrated a spontaneous ovulation, with follicular rupture that occurred between days 15 and 18. This is the first report of a spontaneous ovulation in Turner syndrome evidenced, not only by hormonal analysis, but also by ultrasonographic demonstration of follicular rupture.

Keywords
  • Adult
  • Estradiol/blood
  • Female
  • Follicle Stimulating Hormone/blood
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Luteinizing Hormone/blood
  • Mosaicism
  • Ovary/ultrasonography
  • Ovulation
  • Progesterone/blood
  • Puberty
  • Turner Syndrome/genetics/physiopathology/ultrasonography
Citation (ISO format)
GIACOBINO, Ariane et al. A case of 45,X Turner syndrome with spontaneous ovulation proven by ultrasonography. In: Gynecological endocrinology, 2000, vol. 14, n° 2, p. 105–110. doi: 10.3109/09513590009167668
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0951-3590
539views
0downloads

Technical informations

Creation2015-06-05 10:56:00 AM
First validation2015-06-05 10:56:00 AM
Update time2023-03-14 11:22:27 PM
Status update2023-03-14 11:22:27 PM
Last indexation2024-01-16 6:13:28 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack