UNIGE document Scientific Article
previous document  unige:73157  next document
add to browser collection

Familial adenomatous polyposis-associated thyroid cancer: a clinical, pathological, and molecular genetics study

Sugg, S L
Berk, T
Mitri, A
Cheng, H
Gallinger, S
Cohen, Z
Asa, S L
show hidden authors show all authors [1 - 9]
Published in The American Journal of Pathology. 1999, vol. 154, no. 1, p. 127-35
Abstract We report two familial adenomatous polyposis (FAP) kindreds with thyroid cancer, harboring two apparently novel germlineAPC mutations. The clinical phenotype in the first kindred was typical of classical adenomatous polyposis, whereas the second kindred exhibited an attenuated adenomatous polyposis phenotype. There was a female predominance with a mean age of 34 years (range, 23-49) at cancer diagnosis. Multiple sections of four thyroid tumors from three FAP patients were analyzed in detail. Histological examination of thyroid tumors showed a range of morphological features. Some tumors exhibited typical papillary architecture and were associated with multifocal carcinoma; in others, there were unusual areas of cribriform morphology, and spindle-cell components with whorled architecture. Immunoreactivity for thyroglobulin and high molecular weight keratins was strong. Somatic APC mutation analysis revealed an insertion of a novel long interspersed nuclear element-1-like sequence in one tumor sample, suggesting disruption of APC. In three FAP patients, ret/PTC-1 and ret/PTC-3 were expressed in thyroid cancers. No positivity was observed for ret/ PTC-2. p53 immunohistochemistry was positive in only one section of a recurrent thyroid tumor sample. Our data suggest that genetic alterations in FAP-associated thyroid cancer involve loss of function of APC along with the gain of function of ret/PTC, while alterations of p53 do not appear to be an early event in thyroid tumorigenesis.
Keywords Adenomatous Polyps/complications/geneticsAdultDrosophila ProteinsFemaleGerm-Line Mutation/geneticsHumansImmunohistochemistryMaleMiddle AgedMolecular Biology/methodsNuclear Receptor CoactivatorsOncogene Proteins/geneticsOncogene Proteins, Fusion/geneticsProtein-Tyrosine KinasesProto-Oncogene Proteins/metabolismProto-Oncogene Proteins c-retReceptor Protein-Tyrosine Kinases/metabolismThyroid Neoplasms/complications/genetics/metabolism/pathologyTranscription Factors
PMID: 9916927
Full text
Article (Published version) (959 Kb) - public document Free access
Research group Chirurgie viscérale (104)
(ISO format)
SORAVIA, Claudio et al. Familial adenomatous polyposis-associated thyroid cancer: a clinical, pathological, and molecular genetics study. In: American Journal of Pathology, 1999, vol. 154, n° 1, p. 127-35. doi: 10.1016/S0002-9440(10)65259-5 https://archive-ouverte.unige.ch/unige:73157

258 hits



Deposited on : 2015-06-10

Export document
Format :
Citation style :