en
Scientific article
English

Meropenem (1.5 g/day) is as effective as imipenem/cilastatin (2 g/day) for the treatment of moderately severe intra-abdominal infections

Published inInternational journal of antimicrobial agents, vol. 11, no. 2, p. 107-113
Publication date1999
Abstract

This multicentre, open-label, randomised trial compared meropenem (0.5 g/8 h) and imipenem/cilastatin (at the commonly used dosage of 0.5 g/6 h) in monotherapy in patients with moderately severe intra-abdominal infections (IAIs). In total, 161 patients were randomised (82 meropenem, 79 imipenem/cilastatin). The mean APACHE II scores in the two groups were 5.8 and 6.4, respectively. At the end of therapy, 65/71 (91.6%) evaluable meropenem recipients were clinically cured or improved, compared to 60/64 (93.8%) imipenem/cilastatin recipients. This difference and that in an intention-to-treat analysis (82.1 vs 86.1%, respectively), were not statistically significant. Both drugs were generally well tolerated. Thus, meropenem 0.5 g/8 h is as clinically effective and well tolerated as imipenem/cilastatin 0.5 g/6 h in moderately severe IAIs.

Keywords
  • APACHE
  • Adult
  • Cilastatin/administration & dosage/therapeutic use
  • Drug Therapy, Combination
  • Female
  • Humans
  • Imipenem/administration & dosage/therapeutic use
  • Male
  • Middle Aged
  • Peritonitis/drug therapy
  • Thienamycins/administration & dosage/therapeutic use
Citation (ISO format)
ZANETTI, G et al. Meropenem (1.5 g/day) is as effective as imipenem/cilastatin (2 g/day) for the treatment of moderately severe intra-abdominal infections. In: International journal of antimicrobial agents, 1999, vol. 11, n° 2, p. 107–113. doi: 10.1016/s0924-8579(98)00104-6
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ISSN of the journal0924-8579
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