en
Scientific article
Case report
English

Successful treatment of severe azathioprine-induced hepatic veno-occlusive disease in a kidney-transplanted patient with transjugular intrahepatic portosystemic shunt

Published inClinical nephrology, vol. 50, no. 2, p. 118-122
Publication date1998
Abstract

Azathioprine-induced veno-occlusive disease of the liver mainly described after kidney transplantation is as rare as severe with a high mortality due to acute portal hypertension and liver failure. A kidney-transplanted patient with severe azathioprine-induced veno-occlusive disease of the liver and worsening despite drug discontinuation was treated by emergency transjugular intrahepatic portosystemic shunt. Whereas the veno-occlusive disease was controlled, the patient developed severe intractable portosystemic encephalopathy successfully treated by a stent reducer maintaining a certain degree of portal diversion. Twelve months after transjugular intrahepatic portosystemic shunt, liver function was normalized and the stent was thrombosed with a subnormal liver histology. Thirty-six months after transjugular intrahepatic portosystemic shunt the patient is alive with normal liver function tests and kidney graft function. Transjugular intrahepatic portosystemic shunt for treatment of severe veno-occlusive disease of the liver is an alternative to tide the patient over until recovery of liver function.

Keywords
  • Adult
  • Azathioprine/adverse effects/therapeutic use
  • Biopsy
  • Hepatic Veno-Occlusive Disease/chemically induced/pathology/surgery
  • Humans
  • Immunosuppression
  • Immunosuppressive Agents/adverse effects/therapeutic use
  • Kidney Transplantation
  • Liver/pathology
  • Male
  • Portasystemic Shunt, Transjugular Intrahepatic
Citation (ISO format)
AZOULAY, D et al. Successful treatment of severe azathioprine-induced hepatic veno-occlusive disease in a kidney-transplanted patient with transjugular intrahepatic portosystemic shunt. In: Clinical nephrology, 1998, vol. 50, n° 2, p. 118–122.
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0301-0430
424views
0downloads

Technical informations

Creation06/10/2015 2:27:00 PM
First validation06/10/2015 2:27:00 PM
Update time03/14/2023 11:22:08 PM
Status update03/14/2023 11:22:07 PM
Last indexation01/16/2024 6:12:44 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack