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ATM promoter analysis in childhood lymphoid malignancies: a brief communication

Betts, David R
Published in Leukemia Research. 2006, vol. 30, no. 3, p. 335-7
Abstract ATM promoter hypermethylation has been recently reported in adult carcinomas, but no information is available concerning the methylation status of ATM gene promoter in childhood B-precursor acute lymphoblastic leukaemia (ALL). Furthermore, involvement of somatic ATM promoter mutations in cancer is not known. We report a complete ATM gene promoter analysis in 74 childhood lymphoid malignancies.
Keywords AdultAtaxia Telangiectasia Mutated ProteinsBurkitt Lymphoma/geneticsCarcinoma/geneticsCell Cycle Proteins/geneticsChildChild, PreschoolDNA MethylationDNA-Binding Proteins/geneticsFemaleHumansMalePoint MutationPrecursor Cell Lymphoblastic Leukemia-Lymphoma/geneticsPromoter Regions, Genetic/geneticsProtein-Serine-Threonine Kinases/geneticsSequence Analysis, DNATumor Suppressor Proteins/genetics
PMID: 16125772
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Research group Plateforme d'oncologie et d'hématologie pédiatrique (907)
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GUMY PAUSE, Fabienne et al. ATM promoter analysis in childhood lymphoid malignancies: a brief communication. In: Leukemia Research, 2006, vol. 30, n° 3, p. 335-7. https://archive-ouverte.unige.ch/unige:73118

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Deposited on : 2015-06-09

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