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Population pharmacokinetic/pharmacodynamic modelling of the analgesic effects of tramadol in pediatrics

Published inPharmaceutical research, vol. 23, no. 9, p. 2014-2023
Publication date2006
Abstract

The efficacy of tramadol (T) in children is not clearly understood because it is still unknown the ability of that population to form the active metabolite O-demethyltramadol (M1) and, whether or not the parent compound has a contribution to the efficacy. The aim was to develop a population pharmacokinetic/pharmacodynamic model for T in pediatrics, identifying the main active components.

Keywords
  • Algorithms
  • Analgesics, Opioid/pharmacokinetics/therapeutic use
  • Body Weight/physiology
  • Child
  • Child, Preschool
  • Crying
  • Data Interpretation, Statistical
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Models, Statistical
  • Movement/drug effects
  • Pain, Postoperative/drug therapy/metabolism/psychology
  • Population
  • Predictive Value of Tests
  • Tramadol/pharmacokinetics/therapeutic use
Citation (ISO format)
GARRIDO, María J et al. Population pharmacokinetic/pharmacodynamic modelling of the analgesic effects of tramadol in pediatrics. In: Pharmaceutical research, 2006, vol. 23, n° 9, p. 2014–2023. doi: 10.1007/s11095-006-9049-7
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Article (Published version)
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ISSN of the journal0724-8741
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