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Title

Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study

Authors
Galiè, Nazzareno
Gatzoulis, Michael A
Granton, John
Berger, Rolf M F
Lauer, Andrea
Chiossi, Eleonora
Landzberg, Michael
Published in Circulation. 2006, vol. 114, no. 1, p. 48-54
Abstract Eisenmenger syndrome is characterized by the development of pulmonary arterial hypertension with consequent intracardiac right-to-left shunt and hypoxemia in patients with preexisting congenital heart disease. Because Eisenmenger syndrome is associated with increased endothelin expression, patients may benefit from endothelin receptor antagonism. Theoretically, interventions that have some effect on the systemic vascular bed could worsen the shunt and increase hypoxemia.
Keywords AdultAntihypertensive Agents/therapeutic useDouble-Blind MethodEisenmenger Complex/drug therapy/physiopathologyEndothelin Receptor AntagonistsExercise Tolerance/drug effectsFemaleHemodynamics/drug effectsHumansMaleMiddle AgedOxygen/analysisSulfonamides/therapeutic useTreatment Outcome
Identifiers
PMID: 16801459
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Article (Published version) (272 Kb) - public document Free access
Structures
Research group L'hypertension pulmonaire (pédiatrie) (228)
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GALIÈ, Nazzareno et al. Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study. In: Circulation, 2006, vol. 114, n° 1, p. 48-54. https://archive-ouverte.unige.ch/unige:73113

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Deposited on : 2015-06-09

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