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Title

Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas

Authors
Sander, M
Sussel, L
Conners, J
Scheel, D
Kalamaras, J
Dela Cruz, F
Hayes-Jordan, A
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Published in Development. 2000, vol. 127, no. 24, p. 5533-40
Abstract Most insulin-producing beta-cells in the fetal mouse pancreas arise during the secondary transition, a wave of differentiation starting at embryonic day 13. Here, we show that disruption of homeobox gene Nkx6.1 in mice leads to loss of beta-cell precursors and blocks beta-cell neogenesis specifically during the secondary transition. In contrast, islet development in Nkx6. 1/Nkx2.2 double mutant embryos is identical to Nkx2.2 single mutant islet development: beta-cell precursors survive but fail to differentiate into beta-cells throughout development. Together, these experiments reveal two independently controlled pathways for beta-cell differentiation, and place Nkx6.1 downstream of Nkx2.2 in the major pathway of beta-cell differentiation.
Keywords AnimalsCell DifferentiationGene Expression Regulation, DevelopmentalGenes, HomeoboxHomeodomain Proteins/geneticsIslets of Langerhans/cytology/embryology/metabolismMiceMice, KnockoutMutationPancreas/cytology/embryology/metabolismTranscription Factors/genetics/metabolism
Identifiers
PMID: 11076772
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Article (Published version) (784 Kb) - public document Free access
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Research group Diabète et métabolisme (178)
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SANDER, M et al. Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. In: Development, 2000, vol. 127, n° 24, p. 5533-40. https://archive-ouverte.unige.ch/unige:73095

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Deposited on : 2015-06-09

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