en
Scientific article
Case report
English

Trimethoprim-sulfamethoxazole salvage for refractory listeriosis during maintenance chemotherapy for acute lymphoblastic leukemia

Published inJournal of pediatric hematology/oncology, vol. 22, no. 4, p. 340-343
Publication date2000
Abstract

A 5-year-old boy with acute lymphoblastic leukemia (ALL) and intolerance to oral trimethoprim-sulfamethoxazole (TMP/SMX) had Listeria monocytogenes bacteremia and meningitis develop during maintenance chemotherapy. Despite prompt administration of IV amoxicillin/gentamicin and microbiologic clearance of the bloodstream, the patient had no response to therapy after a course of 7 days. Intravenous TMP/SMX (10 mg/kg per day of TMP) was added to the antibiotic regimen after desensitization. Fever and meningeal signs rapidly resolved, and the patient was ultimately cured. Amoxicillin and gentamicin, although highly active and synergistic in vitro against L. monocytogenes, have limited intracellular penetration and activity. In contrast, TMP/SMX has bactericidal extracellular and intracellular activity against Listeria and excellent central nervous system penetration, and thus may be effective for the treatment of refractory listeriosis.

Keywords
  • Aminoglycosides/therapeutic use
  • Amoxicillin/therapeutic use
  • Anti-Infective Agents/therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols/adverse effects/therapeutic use
  • Bacteremia/drug therapy
  • Child
  • Gentamicins/therapeutic use
  • Humans
  • Male
  • Meningitis, Listeria/drug therapy
  • Penicillin Resistance
  • Penicillins/therapeutic use
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/microbiology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/microbiology
  • Salvage Therapy
  • Trimethoprim-Sulfamethoxazole Combination/therapeutic use
Citation (ISO format)
WACKER, Pierre et al. Trimethoprim-sulfamethoxazole salvage for refractory listeriosis during maintenance chemotherapy for acute lymphoblastic leukemia. In: Journal of pediatric hematology/oncology, 2000, vol. 22, n° 4, p. 340–343. doi: 10.1097/00043426-200007000-00011
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Article (Published version)
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Identifiers
ISSN of the journal1077-4114
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