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Human herpes-virus 8 seropositive patient with skin and graft Kaposi's sarcoma after lung transplantation

Sachsenberg-Studer, EM
Sheldon, J
Schulz, TF
Nador, RG
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Published in Journal of the American Academy of Dermatology. 1999, vol. 40, no. 2 Pt 2, p. 308-11
Abstract Kaposi's sarcoma (KS) has been reported after solid organ transplantation mostly in recipients of renal, liver, heart, and bone allografts. We describe the first case of a patient with lung transplantation who developed KS of the skin, but also of the lung graft. The tumors were localized to places of previous trauma, implying the involvement of a Koebner phenomenon. Moreover, a polymerase chain reaction assay revealed the presence of DNA sequences of herpesvirus 8 (HHV-8) on tissue of the cutaneous KS. Serological tests showed HHV-8 seronegativity of the graft donor and HHV-8 seropositivity of the patient before lung transplantation suggesting that the latter was already infected before the surgery and that immunosuppression resulted in the development of KS. This case report raises the question of the prevalence of HHV-8 in candidates for transplantation and organ donors, and of the value of an antiviral prophylaxis to lower the risk of KS.
Keywords Herpesviridae Infections/diagnosis/immunologyHerpesvirus 8, HumanHumansImmunosuppressionLung Neoplasms/diagnosis/immunologyLung Transplantation/immunologyMaleMiddle AgedOpportunistic Infections/diagnosis/immunologyPolymerase Chain ReactionRisk FactorsSarcoma, Kaposi/diagnosis/immunologySkin Neoplasms/diagnosis/immunology
PMID: 10025855
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SACHSENBERG-STUDER, EM et al. Human herpes-virus 8 seropositive patient with skin and graft Kaposi's sarcoma after lung transplantation. In: Journal of the American Academy of Dermatology, 1999, vol. 40, n° 2 Pt 2, p. 308-11. doi: 10.1016/s0190-9622(99)70472-x https://archive-ouverte.unige.ch/unige:73054

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Deposited on : 2015-06-08

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