Scientific article

Suturing versus immobilization of a muscle laceration. A morphological and functional study in a mouse model

Published inThe American journal of sports medicine, vol. 27, no. 2, p. 222-229
Publication date1999

Muscle laceration remains a difficult problem for orthopaedic surgeons. Despite many studies related to the muscle's ability to regenerate after muscle degeneration, very few reports are available regarding structural and functional recovery after skeletal muscle laceration. We developed an animal model of muscle laceration in mice, where the gastrocnemius muscles were reproducibly transected. We compared the effect of a surgical repair versus a short period of immobilization (5 days) on the muscle healing. The natural course of muscle recovery was monitored at several points after injury using histologic, immunohistochemical, and functional testing. In the injured muscle, we observed a high number of regenerating myofibers and development of fibrotic scar tissue. Suturing the lacerated muscle immediately after injury promoted better healing of the injured muscle and prevented the development of deep scar tissue in the lacerated muscle; conversely, immobilization resulted in slower muscle regeneration and the development of a large area of scar tissue. Tetanus strength 1 month after injury was 81% of control muscles for the sutured muscles, 35% for the lacerated muscles with no treatment, and 18% for the immobilized muscles. Based on this study, suturing a muscle laceration with a modified Kessler stitch results in the best morphologic and functional healing.

  • Analysis of Variance
  • Animals
  • Biological Markers
  • Desmin/metabolism
  • Disease Models, Animal
  • Humans
  • Immobilization
  • Mice
  • Muscle Contraction
  • Muscle, Skeletal/injuries
  • Sutures
  • Vimentin/metabolism
  • Wound Healing
  • Wounds, Penetrating/surgery/therapy
Citation (ISO format)
MENETREY, Jacques et al. Suturing versus immobilization of a muscle laceration. A morphological and functional study in a mouse model. In: The American journal of sports medicine, 1999, vol. 27, n° 2, p. 222–229. doi: 10.1016/s0196-0644(99)80077-8
Main files (1)
Article (Published version)
ISSN of the journal0363-5465

Technical informations

Creation06/02/2015 11:44:00 AM
First validation06/02/2015 11:44:00 AM
Update time03/14/2023 11:20:53 PM
Status update03/14/2023 11:20:52 PM
Last indexation10/18/2023 11:04:23 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack