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Scientific article
English

Peripheral blood progenitor cell mobilization and leukapheresis in pigs

ContributorsNash, K; Chang, Q; Watts, A; Treter, S; Oravec, G; Ferrara, V; Buehler, Leo Hans; Basker, M; Gojo, S; Sachs, D H; White-Scharf, M; Down, J D; Cooper, D K
Published inLaboratory animal science, vol. 49, no. 6, p. 645-649
Publication date1999
Abstract

The pig is being investigated as an organ donor for humans. Induction of immunologic tolerance to pig tissues in primates would overcome the major immunologic barriers to xenotransplantation. A proven method of inducing tolerance to allografts is by the induction of mixed hematopoietic chimerism by bone marrow transplantation. We are therefore investigating induction of mixed hematopoietic chimerism in the pig-to-baboon model.

Keywords
  • Animals
  • Female
  • Granulocyte Colony-Stimulating Factor/pharmacology
  • Hematopoiesis/drug effects
  • Hematopoietic Stem Cell Mobilization/methods/veterinary
  • Hematopoietic Stem Cells/drug effects
  • Humans
  • Interleukin-3/pharmacology
  • Leukapheresis/methods/veterinary
  • Leukocyte Count/drug effects/veterinary
  • Leukocytes/drug effects
  • Male
  • Stem Cell Factor/pharmacology
  • Swine
  • Swine, Miniature/physiology
Affiliation entities
Research groups
Citation (ISO format)
NASH, K et al. Peripheral blood progenitor cell mobilization and leukapheresis in pigs. In: Laboratory animal science, 1999, vol. 49, n° 6, p. 645–649.
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0023-6764
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