en
Scientific article
Review
English

Clinical islet transplantation: a review

Published inAnnals of the New York Academy of Sciences, vol. 875, p. 189-199
Publication date1999
Abstract

For decades, the inability of insulin therapy to physiologically control glycemia in type I diabetic patients has motivated the search for insulin-delivering grafts. Islet autotransplantation is such a therapeutic approach to prevent diabetes mellitus following a major pancreatectomy, whereas allotransplantation is generally prescribed for type I diabetic patients with a functional solid organ graft, or for patients awaiting one. As of today, over 150 patients have been autotransplanted world-wide, following total or subtotal pancreatectomy, permitting an insulin-independence in nearly 40% of patients. Furthermore, more than 350 islet allotransplantations have been performed. Recent results show improved metabolic control in over 50% of cases and insulin-independence in approximately 20%. This chapter presents a literature review including preliminary human islet transplantation data from the University of Geneva.

Keywords
  • Animals
  • Diabetes Mellitus, Type 1/therapy
  • Humans
  • Islets of Langerhans Transplantation
  • Transplantation, Autologous
  • Transplantation, Homologous
Citation (ISO format)
OBERHOLZER, José et al. Clinical islet transplantation: a review. In: Annals of the New York Academy of Sciences, 1999, vol. 875, p. 189–199. doi: 10.1111/j.1749-6632.1999.tb08503.x
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Article (Published version)
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ISSN of the journal0077-8923
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