Scientific article

Le cancer colo-rectal héréditaire sans polyadénomatose associée

Published inAnnales de chirurgie, vol. 53, no. 10, p. 975-978
Publication date1999

Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant condition in which affected individuals develop colorectal cancer or extracolonic cancer, most commonly endometrial, at an early age. Recent advances in molecular genetics have led to the identification of a germline mutation of DNA mismatch-repair genes to be responsible for the majority of HNPPC cases. Since clinical screening of gene carriers can help to prevent cancer, it is important to devise strategies applicable to this syndrome. Recommendations for current management, especially screening and surgical treatment are under study, as they have not yet been clearly established. This paper reviews the clinical presentation, the molecular genetic diagnosis and therapeutic approaches of this syndrome including the controversies concerning prophylactic colectomy for cancer or gene carriers.

  • Adolescent
  • Adult
  • Colectomy
  • Colorectal Neoplasms, Hereditary Nonpolyposis/genetics/surgery
  • DNA, Neoplasm/genetics
  • Female
  • Genetic Testing
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Prognosis
  • Risk Factors
  • Uterine Neoplasms/genetics/prevention & control
Citation (ISO format)
POCARD, M, SORAVIA, Claudio. Le cancer colo-rectal héréditaire sans polyadénomatose associée. In: Annales de chirurgie, 1999, vol. 53, n° 10, p. 975–978.
Main files (1)
Article (Published version)
ISSN of the journal0003-3944

Technical informations

Creation06/03/2015 12:13:00 PM
First validation06/03/2015 12:13:00 PM
Update time03/14/2023 11:20:41 PM
Status update03/14/2023 11:20:41 PM
Last indexation10/18/2023 11:03:59 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack