Scientific article
Open access

Lack of effect of combination antibiotic therapy on mortality in patients with pneumococcal sepsis

Published inEuropean journal of clinical microbiology & infectious diseases, vol. 24, no. 10, p. 688-690
  • Open Access - Licence nationale Springer
Publication date2005

In order to determine whether combination antibiotic therapy decreases mortality after severe pneumococcal infection, a retrospective study of a cohort of 1,840 adult patients with severe sepsis or septic shock enrolled in two multicenter clinical trials between 1994 and 1999 was conducted. Among 107 patients with monobacterial pneumococcal sepsis, the case-fatality rate was 20% (five of 25) for patients who received antibiotic monotherapy compared with 19.5% (16 of 82) for patients who received combination therapy (adjusted hazard ratio, 1.1; 95% CI, 0.4-3.1). Similarly, monotherapy did not increase the risk of death (adjusted hazard ratio, 1.0; 95% CI, 0.2-4.8) among bacteremic patients (n=75). However, the latter analysis may have been underpowered (power, 58%) to detect a difference in mortality. Overall, in contrast to recently published reports, these results suggest that combination antibiotic therapy does not decrease mortality after severe pneumococcal sepsis.

  • Adult
  • Aged
  • Anti-Bacterial Agents/administration & dosage/ therapeutic use
  • Clinical Trials as Topic
  • Drug Therapy, Combination
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multicenter Studies as Topic
  • Pneumococcal Infections/ drug therapy/microbiology/ mortality
  • Sepsis/ drug therapy/microbiology/ mortality
  • Shock, Septic/drug therapy/microbiology/mortality
  • Treatment Outcome
Citation (ISO format)
HARBARTH, Stéphan Juergen et al. Lack of effect of combination antibiotic therapy on mortality in patients with pneumococcal sepsis. In: European journal of clinical microbiology & infectious diseases, 2005, vol. 24, n° 10, p. 688–690. doi: 10.1007/s10096-005-0018-6
Main files (1)
Article (Published version)
ISSN of the journal0934-9723

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