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A general Pd-catalyzed α- and γ-benzylation of aldehydes for the formation of quaternary centers

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Published in Organic and Biomolecular Chemistry. 2015, vol. 13, no. 22, p. 6338-6343
Abstract A palladium-catalyzed benzylation of α-branched aldehydes has been developed using benzyl methyl carbonates. The method gives access to congested quaternary centers in the vicinity of one of the most sensitive carbonyl functionalities and displays unprecedented generality with respect to both coupling partners. Evidence for the direct involvement of a Pd-η3-benzyl intermediate is provided. Extension of this strategy to the γ-benzylation of α,β-unsaturated aldehydes is further demonstrated.
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Other version: http://xlink.rsc.org/?DOI=C5OB00702J
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FRANZONI, Ivan, GUENEE, Laure, MAZET, Clement. A general Pd-catalyzed α- and γ-benzylation of aldehydes for the formation of quaternary centers. In: Organic and Biomolecular Chemistry, 2015, vol. 13, n° 22, p. 6338-6343. https://archive-ouverte.unige.ch/unige:72890

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Deposited on : 2015-06-01

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