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Scientific article
English

A general Pd-catalyzed α- and γ-benzylation of aldehydes for the formation of quaternary centers

Published inOrganic & biomolecular chemistry, vol. 13, no. 22, p. 6338-6343
Publication date2015
Abstract

A palladium-catalyzed benzylation of α-branched aldehydes has been developed using benzyl methyl carbonates. The method gives access to congested quaternary centers in the vicinity of one of the most sensitive carbonyl functionalities and displays unprecedented generality with respect to both coupling partners. Evidence for the direct involvement of a Pd-η3-benzyl intermediate is provided. Extension of this strategy to the γ-benzylation of α,β-unsaturated aldehydes is further demonstrated.

Citation (ISO format)
FRANZONI, Ivan, GUENEE, Laure, MAZET, Clement. A general Pd-catalyzed α- and γ-benzylation of aldehydes for the formation of quaternary centers. In: Organic & biomolecular chemistry, 2015, vol. 13, n° 22, p. 6338–6343. doi: 10.1039/C5OB00702J
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ISSN of the journal1477-0520
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Creation05/28/2015 12:45:00 PM
First validation05/28/2015 12:45:00 PM
Update time03/14/2023 11:20:02 PM
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