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Title

Predominant influence of environmental determinants on the persistence and avidity maturation of antibody responses to vaccines in infants

Authors
Marchant, Arnaud
Goetghebuer, Tessa
Weiss, Helen A
Ota, Martin O C
Whittle, Hilton
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Published in The Journal of Infectious Diseases. 2006, vol. 193, no. 11, p. 1598-605
Abstract Immune responses are complex traits influenced by genetic and environmental factors. We previously reported that genetic factors control early antibody responses to vaccines in Gambian infants. For the present study, we evaluated the determinants of the memory phase of immunoglobulin G (IgG) responses.
Keywords AgingAntibodies, Bacterial/bloodAntibodies, Viral/bloodAntibody AffinityAntibody Formation/geneticsEnvironmentEnzyme-Linked Immunosorbent AssayGambiaHumansImmunoglobulin G/bloodInfantMeasles Vaccine/administration & dosage/immunologyTetanus Toxoid/administration & dosage/immunologyTwins, DizygoticTwins, MonozygoticVaccines/administration & dosage/immunology
Identifiers
PMID: 16652290
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Article (Published version) (268 Kb) - public document Free access
Structures
Research group Centre de Vaccinologie et d'Immunologie néonatale (177)
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MARCHANT, Arnaud et al. Predominant influence of environmental determinants on the persistence and avidity maturation of antibody responses to vaccines in infants. In: The Journal of Infectious Diseases, 2006, vol. 193, n° 11, p. 1598-605. https://archive-ouverte.unige.ch/unige:72878

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Deposited on : 2015-05-28

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