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Predominant influence of environmental determinants on the persistence and avidity maturation of antibody responses to vaccines in infants

ContributorsMarchant, Arnaud; Pihlgren Bosch, Maria Astrid Louise; Goetghebuer, Tessa; Weiss, Helen A; Ota, Martin O C; Schlegel Heueter, Susanna; Whittle, Hilton; Lambert, Paul Henri; Newport, Melanie J; Siegrist, Claire-Anne
Published inThe Journal of infectious diseases, vol. 193, no. 11, p. 1598-1605
Publication date2006
Abstract

Immune responses are complex traits influenced by genetic and environmental factors. We previously reported that genetic factors control early antibody responses to vaccines in Gambian infants. For the present study, we evaluated the determinants of the memory phase of immunoglobulin G (IgG) responses.

Keywords
  • Aging
  • Antibodies, Bacterial/blood
  • Antibodies, Viral/blood
  • Antibody Affinity
  • Antibody Formation/genetics
  • Environment
  • Enzyme-Linked Immunosorbent Assay
  • Gambia
  • Humans
  • Immunoglobulin G/blood
  • Infant
  • Measles Vaccine/administration & dosage/immunology
  • Tetanus Toxoid/administration & dosage/immunology
  • Twins, Dizygotic
  • Twins, Monozygotic
  • Vaccines/administration & dosage/immunology
Affiliation
Research group
Citation (ISO format)
MARCHANT, Arnaud et al. Predominant influence of environmental determinants on the persistence and avidity maturation of antibody responses to vaccines in infants. In: The Journal of infectious diseases, 2006, vol. 193, n° 11, p. 1598–1605. doi: 10.1086/503775
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0022-1899
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290downloads

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