Predominant influence of environmental determinants on the persistence and avidity maturation of antibody responses to vaccines in infants

Marchant, Arnaud; Pihlgren Bosch, Maria Astrid Louise; Goetghebuer, Tessa; Weiss, Helen A; Ota, Martin O C; Schlegel Heueter, Susanna; Whittle, Hilton; Lambert, Paul Henri; Newport, Melanie J; Siegrist, Claire-Anne

doi:10.1086/503775

Article scientifique

Accès libre

Anglais

Predominant influence of environmental determinants on the persistence and avidity maturation of antibody responses to vaccines in infants

Contributeurs/tricesMarchant, Arnaud; Pihlgren Bosch, Maria Astrid Louise; Goetghebuer, Tessa; Weiss, Helen A; Ota, Martin O C; Schlegel Heueter, Susanna; Whittle, Hilton; Lambert, Paul Henri; Newport, Melanie J; Siegrist, Claire-Anne

Publié dansThe Journal of infectious diseases, vol. 193, no. 11, p. 1598-1605

Date de publication2006

Résumé

Immune responses are complex traits influenced by genetic and environmental factors. We previously reported that genetic factors control early antibody responses to vaccines in Gambian infants. For the present study, we evaluated the determinants of the memory phase of immunoglobulin G (IgG) responses.

Mots-clés

Aging
Antibodies, Bacterial/blood
Antibodies, Viral/blood
Antibody Affinity
Antibody Formation/genetics
Environment
Enzyme-Linked Immunosorbent Assay
Gambia
Humans
Immunoglobulin G/blood
Infant
Measles Vaccine/administration & dosage/immunology
Tetanus Toxoid/administration & dosage/immunology
Twins, Dizygotic
Twins, Monozygotic
Vaccines/administration & dosage/immunology

Structure d'affiliation

Groupe de recherche

Centre de Vaccinologie et d'Immunologie néonatale (177)

Citation (format ISO)

MARCHANT, Arnaud et al. Predominant influence of environmental determinants on the persistence and avidity maturation of antibody responses to vaccines in infants. In: The Journal of infectious diseases, 2006, vol. 193, n° 11, p. 1598–1605. doi: 10.1086/503775

Article (Published version)

Identifiants

PID : unige:72878
DOI : 10.1086/503775
PMID : 16652290

ISSN du journal0022-1899

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Première validation29.01.2015 15:00:00

Heure de mise à jour14.03.2023 23:19:55

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Predominant influence of environmental determinants on the persistence and avidity maturation of antibody responses to vaccines in infants

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