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Analysis of HIV-1- and CMV-specific memory CD4 T-cell responses during primary and chronic infection

Harari, Alexandre
Rizzardi, G. P.
Ellefsen, Kim
Champagne, Patrick
Bart, P. A.
Kaufmann, Daniel
Telenti, Amalio
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Published in Blood. 2002, vol. 100, no. 4, p. 1381-1387
Abstract CD4 T-cell-specific memory antiviral responses to human immunodeficiency virus type 1 (HIV-1) and cytomegalovirus (CMV) were investigated in 16 patients with documented primary HIV-1 infection (4 of the 16 subjects also had primary CMV infection) and compared with those observed in patients with chronic HIV-1 and CMV coinfection. Virus-specific memory CD4 T cells were characterized on the basis of the expression of the chemokine receptor CCR7. HIV-1- and CMV-specific interferon-gamma-secreting CD4 T cells were detected in patients with primary and chronic HIV-1 and CMV coinfection and were mostly contained in the cell population lacking expression of CCR7. The magnitude of the primary CMV-specific CD4 T-cell response was significantly greater than that of chronic CMV infection, whereas there were no differences between primary and chronic HIV-1-specific CD4 T-cell responses. A substantial proportion of CD4(+)CCR7(-) T cells were infected with HIV-1. These results advance the characterization of antiviral memory CD4 T-cell response and the delineation of the potential mechanisms that likely prevent the generation of a robust CD4 T-cell immune response during primary infection.
Keywords Acquired Immunodeficiency Syndrome/complications/ immunologyAdultAntibodies, Viral/bloodCD4-Positive T-Lymphocytes/ immunologyChronic DiseaseCytomegalovirus/immunologyCytomegalovirus Infections/complications/ immunologyFemaleHIV-1/ immunologyHumansImmunologic MemoryMalePhenotypeReceptors, CCR7Receptors, Chemokine/analysisViral LoadViremia
PMID: 12149221
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HARARI, Alexandre et al. Analysis of HIV-1- and CMV-specific memory CD4 T-cell responses during primary and chronic infection. In: Blood, 2002, vol. 100, n° 4, p. 1381-1387. doi: 10.1182/blood-2001-11-0080 https://archive-ouverte.unige.ch/unige:7287

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Deposited on : 2010-06-21

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