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Hepatic vascular response to norepinephrine during endotoxemia in anesthetized pigs

Published in Shock. 1999, vol. 12, no. 4, p. 294-9
Abstract To investigate the systemic and hepatic reactivity to norepinephrine (NE) during chronic endotoxemia, we measured the reactivity of the drug in pigs infused with endotoxin (End, 160 ng/kg/min) during an 18-h period. At the end of the experiments, the hepatic vessels were removed to test the hepatic vascular reactivity in vitro. The pressive response to NE did not change over time in control (Ctrl) pigs, but endotoxin infusion decreased the response at t = 11 and 17 h. The reactivity of the portal vein blood flow did not change in Ctrl pigs but was significantly increased in End pigs at t = 5 h. Finally, endotoxin decreased the contractile response to NE only in transversal strips of portal veins isolated from End pigs. Thus, in this model, the decreased pressive response to NE develops over time, but the modifications of the hepatic vascular reactivity remain minor.
Keywords AnestheticsAnimalsChronic DiseaseEndotoxemia/drug therapyFemaleHemodynamics/drug effectsHepatic Veins/drug effectsMaleNorepinephrine/pharmacologyPortal Vein/drug effectsSwineSwine, MiniatureVasoconstrictor Agents/pharmacology
PMID: 10509632
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Research groups Groupe Iselin Christophe (urologie) (106)
Pharmacologie et imagerie du foie (664)
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MASTRANGELO, Domenico, PASTOR, Catherine. Hepatic vascular response to norepinephrine during endotoxemia in anesthetized pigs. In: Shock, 1999, vol. 12, n° 4, p. 294-9. doi: 10.1097/00024382-199910000-00008 https://archive-ouverte.unige.ch/unige:72852

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Deposited on : 2015-05-28

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