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Scientific article
Case report
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English

Long term inhalation of iloprost in a child with primary pulmonary hypertension: an alternative to continuous infusion

Contributors

Beghetti, Maurice; Berner, Michel; Rimensberger, Peter

Published in

Heart, vol. 86, no. 3, E10

Publication date

2001

Abstract

Primary pulmonary hypertension is a rare disease in childhood associated with a poor prognosis. However, during the past 10 years, pulmonary vasodilator treatment has somewhat improved its prognosis. Long term continuous infusion of prostacyclin (epoprostenol) has been shown to improve physical capacity and to reduce mortality in primary and secondary pulmonary hypertension. It has been reported in adults that daily repetitive inhalation of iloprost, a prostacyclin analogue, seems also suitable for long term therapy of pulmonary hypertension. Repetitive inhalation of iloprost was administered to a 5 year old boy with severe primary pulmonary hypertension. He showed continuous clinical improvement without any side effects over the three years of treatment. This treatment may offer an alternative to continuous intravenous prostacyclin infusion and obviates the need for a permanent central venous catheter.

Keywords

  • Administration, Inhalation
  • Child, Preschool
  • Humans
  • Hypertension, Pulmonary/drug therapy
  • Iloprost/administration & dosage
  • Male
  • Vasodilator Agents/administration & dosage

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

BEGHETTI, Maurice, BERNER, Michel, RIMENSBERGER, Peter. Long term inhalation of iloprost in a child with primary pulmonary hypertension: an alternative to continuous infusion. In: Heart, 2001, vol. 86, n° 3, p. E10. doi: 10.1136/heart.86.3.e10

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

1468-201X
559views
242downloads

Technical informations

Creation

06/05/2015 10:48:00

First validation

06/05/2015 10:48:00

Update

14/03/2023 23:18:57

Status update

14/03/2023 23:18:57

Last indexation

31/10/2024 00:18:38
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