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Title

The problem of anti-pig antibodies in pig-to-primate xenografting: current and novel methods of depletion and/or suppression of production of anti-pig antibodies

Authors
Alwayn, I P
Basker, M
Cooper, D K
Published in Xenotransplantation. 1999, vol. 6, no. 3, p. 157-68
Abstract The role of antibodies directed against Galalpha1-3Gal (alpha-Gal) epitopes in porcine-to-primate xenotransplantation has been widely studied during the past few years. These antibodies (anti-alpha-Gal) have been associated with both hyperacute rejection and acute vascular rejection of vascularized organs. Depletion and (temporary or permanent) suppression of production of anti-alpha-Gal seem to be essential to the long-term survival of these organs, even when the ultimate aim is accommodation or tolerance. Although more than 95% depletion of anti-alpha-Gal can be achieved by the use of immunoaffinity column technology, to date no regimen has been successful in preventing the return of anti-alpha-Gal (from continuing production). In this review, we discuss current and novel methods for achieving depletion or inhibition (i.e. extracorporeal immunoadsorption, anti-idiotypic antibodies, the intravenous infusion of immunoglobulin or oligosaccharides) and suppression of production (i.e. irradiation, pharmacologic agents, specific monoclonal antibodies, immunotoxins) of anti-alpha-Gal antibodies.
Keywords AnimalsAntibody FormationDisaccharides/antagonists & inhibitors/immunologyEpitopes/immunologyGraft Rejection/immunologyGraft Survival/immunologyOrgan TransplantationPrimatesSwineTransplantation ImmunologyTransplantation, Heterologous
Identifiers
PMID: 10503781
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Research group Cultures cellulaires et transplantations (519)
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ALWAYN, I P et al. The problem of anti-pig antibodies in pig-to-primate xenografting: current and novel methods of depletion and/or suppression of production of anti-pig antibodies. In: Xenotransplantation, 1999, vol. 6, n° 3, p. 157-68. https://archive-ouverte.unige.ch/unige:72758

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Deposited on : 2015-05-21

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