en
Scientific article
Review
English

The problem of anti-pig antibodies in pig-to-primate xenografting: current and novel methods of depletion and/or suppression of production of anti-pig antibodies

Published inXenotransplantation, vol. 6, no. 3, p. 157-168
Publication date1999
Abstract

The role of antibodies directed against Galalpha1-3Gal (alpha-Gal) epitopes in porcine-to-primate xenotransplantation has been widely studied during the past few years. These antibodies (anti-alpha-Gal) have been associated with both hyperacute rejection and acute vascular rejection of vascularized organs. Depletion and (temporary or permanent) suppression of production of anti-alpha-Gal seem to be essential to the long-term survival of these organs, even when the ultimate aim is accommodation or tolerance. Although more than 95% depletion of anti-alpha-Gal can be achieved by the use of immunoaffinity column technology, to date no regimen has been successful in preventing the return of anti-alpha-Gal (from continuing production). In this review, we discuss current and novel methods for achieving depletion or inhibition (i.e. extracorporeal immunoadsorption, anti-idiotypic antibodies, the intravenous infusion of immunoglobulin or oligosaccharides) and suppression of production (i.e. irradiation, pharmacologic agents, specific monoclonal antibodies, immunotoxins) of anti-alpha-Gal antibodies.

Keywords
  • Animals
  • Antibody Formation
  • Disaccharides/antagonists & inhibitors/immunology
  • Epitopes/immunology
  • Graft Rejection/immunology
  • Graft Survival/immunology
  • Organ Transplantation
  • Primates
  • Swine
  • Transplantation Immunology
  • Transplantation, Heterologous
Citation (ISO format)
ALWAYN, I P et al. The problem of anti-pig antibodies in pig-to-primate xenografting: current and novel methods of depletion and/or suppression of production of anti-pig antibodies. In: Xenotransplantation, 1999, vol. 6, n° 3, p. 157–168. doi: 10.1034/j.1399-3089.1999.00030.x
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Article (Published version)
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ISSN of the journal0908-665X
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