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Title

In vitro decrease of glomerular heparan sulfate by lymphocytes from idiopathic nephrotic syndrome patients
Authors
Birmele, Béatrice
Thibault, G
Nivet, H
De Agostini, Ariane
Girardin, Eric
Published in Kidney International. 2001, vol. 59, no. 3, p. 913-22
Abstract Lymphocytes are involved in the physiopathologic mechanism of idiopathic nephrotic syndrome (INS). We have recently demonstrated that plasma from patients with INS decreases human glomerular epithelial cell (GEC) glycosaminoglycans (GAGs), particularly heparan sulfates (HS) in vitro. In this study we investigate the effect of peripheral blood lymphocytes (PBL) from INS patients on glomerular cell GAG and HS.
Keywords Cells, Cultured — Child — Chondroitin Sulfates/metabolism — Glycosaminoglycans/chemistry/metabolism — Heparitin Sulfate/antagonists & inhibitors — Humans — Kidney Glomerulus/metabolism/pathology — Lymphocytes/physiology — Monocytes/physiology — Nephrotic Syndrome/metabolism/pathology — Polymers/metabolism — Reference Values
Identifiers
PMID: 11231346
Full text
Article (Published version) (2.2 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research group Pathogénèse du syndrome néphrotique idiopathique de l'enfant (180)
Citation
(ISO format) 		BIRMELE, Béatrice et al. In vitro decrease of glomerular heparan sulfate by lymphocytes from idiopathic nephrotic syndrome patients. In: Kidney International, 2001, vol. 59, n° 3, p. 913-22. doi: 10.1046/j.1523-1755.2001.059003913.x https://archive-ouverte.unige.ch/unige:72744

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Deposited on : 2015-05-21

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