en
Scientific article
English

In vitro decrease of glomerular heparan sulfate by lymphocytes from idiopathic nephrotic syndrome patients

Published inKidney international, vol. 59, no. 3, p. 913-922
Publication date2001
Abstract

Lymphocytes are involved in the physiopathologic mechanism of idiopathic nephrotic syndrome (INS). We have recently demonstrated that plasma from patients with INS decreases human glomerular epithelial cell (GEC) glycosaminoglycans (GAGs), particularly heparan sulfates (HS) in vitro. In this study we investigate the effect of peripheral blood lymphocytes (PBL) from INS patients on glomerular cell GAG and HS.

Keywords
  • Cells, Cultured
  • Child
  • Chondroitin Sulfates/metabolism
  • Glycosaminoglycans/chemistry/metabolism
  • Heparitin Sulfate/antagonists & inhibitors
  • Humans
  • Kidney Glomerulus/metabolism/pathology
  • Lymphocytes/physiology
  • Monocytes/physiology
  • Nephrotic Syndrome/metabolism/pathology
  • Polymers/metabolism
  • Reference Values
Citation (ISO format)
BIRMELE, Béatrice et al. In vitro decrease of glomerular heparan sulfate by lymphocytes from idiopathic nephrotic syndrome patients. In: Kidney international, 2001, vol. 59, n° 3, p. 913–922. doi: 10.1046/j.1523-1755.2001.059003913.x
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0085-2538
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