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Scientific article
English

Improvement of the effect of hepatocyte isograft in the Gunn rat by cotransplantation of islets of Langerhans

Published inJournal of pediatric surgery, vol. 34, no. 2, p. 321-324
Publication date1999
Abstract

Hepatocyte transplantation (HcTX) has been investigated for many years as an alternative therapy to orthotopic liver transplantation to treat hepatic congenital enzymatic deficiency disease. The animal model most used is the Gunn rat, which presents a hyperbilirubinemia caused by the lack of uridine-diphosphate-glucuronyl-transferase. Some investigators have clearly described a hepatotrophic effect mediated by islets of Langerhans (IL) when transplanted with hepatocytes (Hc). In this study, the functional effect of cotransplanted IL on hepatocytes (co-HcTX) in Gunn rats in an isograft model is assessed.

Keywords
  • Analysis of Variance
  • Animals
  • Blood Glucose/analysis
  • Cell Transplantation/physiology
  • Disease Models, Animal
  • Hyperbilirubinemia/blood/surgery
  • Islets of Langerhans Transplantation/physiology
  • Liver/cytology
  • Liver Transplantation/physiology
  • Rats
  • Rats, Gunn
  • Spleen/surgery
  • Statistics, Nonparametric
Citation (ISO format)
GENIN, Bernard et al. Improvement of the effect of hepatocyte isograft in the Gunn rat by cotransplantation of islets of Langerhans. In: Journal of pediatric surgery, 1999, vol. 34, n° 2, p. 321–324. doi: 10.1016/S0022-3468(99)90200-2
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Article (Published version)
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Identifiers
ISSN of the journal0022-3468
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