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Title

Improvement of the effect of hepatocyte isograft in the Gunn rat by cotransplantation of islets of Langerhans

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Published in Journal of Pediatric Surgery. 1999, vol. 34, no. 2, p. 321-4
Abstract Hepatocyte transplantation (HcTX) has been investigated for many years as an alternative therapy to orthotopic liver transplantation to treat hepatic congenital enzymatic deficiency disease. The animal model most used is the Gunn rat, which presents a hyperbilirubinemia caused by the lack of uridine-diphosphate-glucuronyl-transferase. Some investigators have clearly described a hepatotrophic effect mediated by islets of Langerhans (IL) when transplanted with hepatocytes (Hc). In this study, the functional effect of cotransplanted IL on hepatocytes (co-HcTX) in Gunn rats in an isograft model is assessed.
Keywords Analysis of VarianceAnimalsBlood Glucose/analysisCell Transplantation/physiologyDisease Models, AnimalHyperbilirubinemia/blood/surgeryIslets of Langerhans Transplantation/physiologyLiver/cytologyLiver Transplantation/physiologyRatsRats, GunnSpleen/surgeryStatistics, Nonparametric
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PMID: 10052814
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Research groups Métastases du foie (657)
Chirurgie viscérale (104)
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GENIN, Bernard et al. Improvement of the effect of hepatocyte isograft in the Gunn rat by cotransplantation of islets of Langerhans. In: Journal of Pediatric Surgery, 1999, vol. 34, n° 2, p. 321-4. https://archive-ouverte.unige.ch/unige:72648

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Deposited on : 2015-05-18

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