Scientific article

Respiratory viruses and severe lower respiratory tract complications in hospitalized patients

Published inChest, vol. 125, no. 3, p. 1033-1039
Publication date2004

BACKGROUND: Acute respiratory viral infections are generally self-limited in healthy subjects but can lead to severe complications in immunocompromised hosts. We report the clinical impact of acute lower respiratory tract viral infections in hospitalized patients. MATERIALS AND METHODS: Of 1,001 fiberoptic bronchoscopies performed during a period of 5 years, 33 BAL samples were positive for respiratory viruses by cell culture. The main diagnosis, length of hospitalization, response to initial treatment, and the mortality rate at 30 days were analyzed. Spirometry performed before and after infection was compared in lung transplant recipients. RESULTS: The following respiratory viruses were identified in 33 cases: influenza A or B (n = 13), parainfluenza virus 1-3 (n = 7), rhinovirus (n = 5), respiratory syncytial virus (n = 4), and adenovirus (n = 4). All cases were immunocompromised patients who acquired new respiratory symptoms and/or radiologic abnormalities suggesting a pulmonary infection. Twenty-five patients (74%) did not respond to initial broad-spectrum antibiotics, and 11 patients (33%) required intensive care for respiratory failure. The overall mortality rate at 1 month was 24%. In patients with a sole viral pathogen identified in their BAL, the mortality rate was 39%. In lung transplant recipients (n = 10), the mean FEV(1) decreased from 2.2 to 1.9 L/s before and during the infection episode, respectively (p < 0.01); 3 months later, 60% of the patients had still not completely recovered to baseline values. CONCLUSION: Respiratory viruses recovered in BAL samples of immunocompromised patients are associated with severe lower respiratory complications. In lung transplant recipients, we observed a persisting impairment of pulmonary function.

  • Acute Disease
  • Adolescent
  • Adult
  • Aged
  • Cross Infection/diagnosis/virology
  • Female
  • Hospitalization
  • Humans
  • Immunocompromised Host
  • Lung Transplantation/immunology
  • Male
  • Middle Aged
  • Respiratory Tract Infections/ complications/diagnosis/mortality/virology
  • Survival Rate
  • Virus Diseases/ complications/diagnosis/mortality/virology
Citation (ISO format)
GARBINO, Jorge et al. Respiratory viruses and severe lower respiratory tract complications in hospitalized patients. In: Chest, 2004, vol. 125, n° 3, p. 1033–1039.
Updates (1)
ISSN of the journal0012-3692

Technical informations

Creation06/21/2010 10:24:17 AM
First validation06/21/2010 10:24:17 AM
Update time03/14/2023 3:43:43 PM
Status update03/14/2023 3:43:43 PM
Last indexation10/18/2023 9:22:42 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack