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Title

Contribution of clumping factor B to pathogenesis of experimental endocarditis due to Staphylococcus aureus

Authors
Entenza, J. M.
Foster, T. J.
Ni Eidhin, D.
Francioli, Patrick
Published in Infection and Immunity. 2000, vol. 68, no. 9, p. 5443-5446
Abstract Staphylococcus aureus Newman with an insertion mutation in clfB, the gene encoding clumping factor B, only marginally decreased infection rate (P>0.05) in rats with experimental endocarditis. In contrast, clfB complementation on a multicopy plasmid significantly increased infectivity (P<0.05) over the deleted mutants. Although clfB could affect endovascular infection, its importance in experimental endocarditis was limited.
Keywords Adhesins, Bacterial/ physiologyAnimalsEndocarditis, Bacterial/ etiologyFibrinogen/ metabolismRatsStaphylococcal Infections/ etiology
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PMID: 10948180
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ENTENZA, J. M. et al. Contribution of clumping factor B to pathogenesis of experimental endocarditis due to Staphylococcus aureus. In: Infection and Immunity, 2000, vol. 68, n° 9, p. 5443-5446. https://archive-ouverte.unige.ch/unige:7193

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Deposited on : 2010-06-21

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