Scientific article

Acute respiratory distress syndrome after bacteremic sepsis does not increase mortality

Published inAmerican journal of respiratory and critical care medicine, vol. 167, no. 9, p. 1210-1214
Publication date2003

To determine whether acute respiratory distress syndrome (ARDS) complicating bacteremic sepsis independently affects mortality in critically ill patients, we conducted a 3-year retrospective cohort study in a surgical intensive care unit. We included all consecutive patients with blood culture-positive sepsis and measured organ dysfunctions and mortality. Among 4,530 admissions, 196 cases of bacteremic sepsis were recorded. ARDS occurred in 31 (16%) of these patients. The case fatality rate was 58% in patients with ARDS compared with 31% in patients without ARDS. Using Cox proportional hazards regression with time-dependent variables, the unadjusted hazard ratio for death was 1.8 (95% confidence interval [CI], 1.0-3.2). After adjusting for comorbid factors that were present before the onset of sepsis, the hazard ratio was 2.2 (95% CI, 1.2-3.9). After further adjustment was made for nonpulmonary organ dysfunctions and microbiologic factors that were independently associated with mortality, the adjusted hazard ratio for ARDS was 0.6 (95% CI, 0.3-1.2). Among critically ill surgical patients, ARDS complicating bacteremic sepsis remains common, but it is not independently associated with short-term mortality, after adjusting for severity of illness and nonpulmonary organ dysfunctions evolving after the onset of sepsis.

  • Apache
  • Acute Disease
  • Aged
  • Analysis of Variance
  • Bacteremia/blood/ complications/ mortality
  • Cause of Death
  • Comorbidity
  • Critical Illness
  • Female
  • Hospital Mortality
  • Hospitals, University
  • Humans
  • Length of Stay/statistics & numerical data
  • Male
  • Middle Aged
  • Prognosis
  • Proportional Hazards Models
  • Respiratory Distress Syndrome, Adult/ microbiology
  • Retrospective Studies
  • Risk Factors
  • Severity of Illness Index
  • Survival Analysis
  • Switzerland/epidemiology
Citation (ISO format)
EGGIMANN, Philippe et al. Acute respiratory distress syndrome after bacteremic sepsis does not increase mortality. In: American journal of respiratory and critical care medicine, 2003, vol. 167, n° 9, p. 1210–1214. doi: 10.1164/rccm.200210-1196OC
Updates (1)
ISSN of the journal1073-449X

Technical informations

Creation21/06/2010 10:23:48
First validation21/06/2010 10:23:48
Update time14/03/2023 15:43:17
Status update14/03/2023 15:43:17
Last indexation25/09/2023 07:48:36
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