UNIGE document Scientific Article
previous document  unige:7177  next document
add to browser collection

Management of Candida species infections in critically ill patients

Published in The Lancet Infectious Diseases. 2003, vol. 3, no. 12, p. 772-785
Abstract Invasive candidiasis is a feared infection with mortality similar to that of septic shock (40-60%). Improved knowledge of its pathophysiology and the availability of new compounds for antifungal therapy and prophylaxis have contributed to improving the prognosis of severe candidal infections among immunosuppressed patients at the possible cost of the emergence of non-albicans strains of candida with lower susceptibility to azoles. This review focuses on the management of invasive deep-seated candidiasis in critically ill, non-immunocompromised patients. We discuss antifungal use, indications, potential benefit, and main secondary effects. Prevention strategies include pre-emptive antifungal therapy and azole-based prophylaxis. For patients at lower initial risk, pre-emptive therapy should be based on a management strategy that takes into account the presence of definite risk factors and the dynamics of candida colonisation. Among critically ill patients, azole prophylaxis is effective and is not associated with acquisition of resistance; it must be restricted to highly selected groups of patients at high risk only.
Keywords Amphotericin B/therapeutic useAntifungal Agents/ therapeutic useAzoles/therapeutic useCandidiasis/ prevention & controlClinical Trials as TopicCritical IllnessHumansImmunocompetenceNystatin/therapeutic usePractice Guidelines as Topic
PMID: 14652203
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Research group Staphylocoques dorés résistants à la méthicilline et hygiène hospitalière (330)
(ISO format)
EGGIMANN, Philippe, GARBINO, Jorge, PITTET, Didier. Management of Candida species infections in critically ill patients. In: The Lancet Infectious Diseases, 2003, vol. 3, n° 12, p. 772-785. https://archive-ouverte.unige.ch/unige:7177

327 hits

0 download


Deposited on : 2010-06-21

Export document
Format :
Citation style :