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Selective inhibition of nuclear steroid receptor function by a protein from a human tumorigenic poxvirus

Chen, N.
Baudino, T.
MacDonald, P. N.
Green, M.
Burnett, J. W.
Buller, R. M.
Published in Virology. 2000, vol. 274, no. 1, p. 17-25
Abstract The poxvirus molluscum contagiosum (MC) has a worldwide distribution and its prevalence is on the rise. Here we report that the MCV MC013L protein inhibits glucocorticoid and vitamin D, but not retinoid or estrogen, nuclear receptor transactivation. A direct interaction of MC013L with glucocorticoid and vitamin D receptor is supported by yeast two-hybrid, GST pull-down, and far Western blot analyses. Glucocorticoids act as potent inhibitors of keratinocyte proliferation, while vitamin D and retinoids promote and block terminal differentiation, respectively. Therefore, MC013L may promote efficient virus replication by blocking the differentiation of infected keratinocytes. MC013L may be the first member of a new class of poxvirus proteins that directly modulate nuclear receptor-mediated transcription.
Keywords Amino Acid SequenceAnimalsCOS CellsCalcitriol/metabolismCell NucleusGene ExpressionGenes, ReporterGrowth Substances/geneticsHSP40 Heat-Shock ProteinsHeat-Shock Proteins/genetics/metabolism/ physiologyHumansMolecular Sequence DataMolluscum contagiosum virus/genetics/metabolism/ physiologyReceptors, Calcitriol/antagonists & inhibitors/geneticsReceptors, Estrogen/antagonists & inhibitors/geneticsReceptors, Glucocorticoid/antagonists & inhibitors/geneticsReceptors, Retinoic Acid/metabolismReceptors, Steroid/ antagonists & inhibitors/geneticsSequence Homology, Amino AcidTranscription, GeneticViral Proteins/genetics/metabolism/ physiologyVirus Replication/physiology
PMID: 10936084
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CHEN, N. et al. Selective inhibition of nuclear steroid receptor function by a protein from a human tumorigenic poxvirus. In: Virology, 2000, vol. 274, n° 1, p. 17-25. https://archive-ouverte.unige.ch/unige:7141

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Deposited on : 2010-06-21

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