Scientific article

Low bone mineral density, renal dysfunction, and fracture risk in HIV infection: a cross-sectional study

Published inThe Journal of infectious diseases, vol. 200, no. 11, p. 1746-1754
Publication date2009

BACKGROUND: Reduced bone mineral density (BMD) is common in adults infected with human immunodeficiency virus (HIV). The role of proximal renal tubular dysfunction (PRTD) and alterations in bone metabolism in HIV-related low BMD are incompletely understood. METHODS: We quantified BMD (dual-energy x-ray absorptiometry), blood and urinary markers of bone metabolism and renal function, and risk factors for low BMD (hip or spine T score, -1 or less) in an ambulatory care setting. We determined factors associated with low BMD and calculated 10-year fracture risks using the World Health Organization FRAX equation. RESULTS: We studied 153 adults (98% men; median age, 48 years; median body mass index, 24.5; 67 [44%] were receiving tenofovir, 81 [53%] were receiving a boosted protease inhibitor [PI]). Sixty-five participants (42%) had low BMD, and 11 (7%) had PRTD. PI therapy was associated with low BMD in multivariable analysis (odds ratio, 2.69; 95% confidence interval, 1.09-6.63). Tenofovir use was associated with increased osteoblast and osteoclast activity (P< or =.002). The mean estimated 10-year risks were 1.2% for hip fracture and 5.4% for any major osteoporotic fracture. CONCLUSIONS: In this mostly male population, low BMD was significantly associated with PI therapy. Tenofovir recipients showed evidence of increased bone turnover. Measurement of BMD and estimation of fracture risk may be warranted in treated HIV-infected adults.

  • Adult
  • Analysis of Variance
  • Anti-Retroviral Agents/therapeutic use
  • Bone Density
  • Cross-Sectional Studies
  • Fanconi Syndrome/metabolism/pathology/ virology
  • Female
  • Fractures, Bone/metabolism/ virology
  • HIV Infections/drug therapy/ metabolism/pathology
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Prevalence
  • Risk Factors
  • Statistics, Nonparametric
Research group
Citation (ISO format)
CALMY, Alexandra et al. Low bone mineral density, renal dysfunction, and fracture risk in HIV infection: a cross-sectional study. In: The Journal of infectious diseases, 2009, vol. 200, n° 11, p. 1746–1754. doi: 10.1086/644785
Updates (1)
ISSN of the journal0022-1899

Technical informations

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