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Serotonin syndrome after concomitant treatment with linezolid and citalopram

Published in Clinical Infectious Diseases. 2003, vol. 36, no. 9, p. 1197
Abstract Linezolid, a new synthetic antimicrobial, is an important weapon against methicillin-resistant Staphylococcus aureus (MRSA). Although there are reports of serotonin syndrome developing after concomitant use of linezolid and the selective serotonin reuptake inhibitor paroxitene, this report concerns a patient receiving citalopram who developed thrombocytopenia, serotonin syndrome, and lactic acidosis and died following long-term linezolid therapy.
Keywords Acetamides/ adverse effectsAcidosis, Lactic/chemically inducedCitalopram/ adverse effectsDrug CombinationsHumansOxazolidinones/ adverse effectsProtein Synthesis Inhibitors/adverse effectsSerotonin Syndrome/ chemically inducedSerotonin Uptake Inhibitors/adverse effectsStaphylococcus aureus/drug effectsThrombocytopenia/chemically induced
PMID: 12715317
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Other version: http://www.journals.uchicago.edu/doi/full/10.1086/374558
Research group Chirurgie orthopédique et traumatologique (98)
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BERNARD, Louis et al. Serotonin syndrome after concomitant treatment with linezolid and citalopram. In: Clinical Infectious Diseases, 2003, vol. 36, n° 9, p. 1197. https://archive-ouverte.unige.ch/unige:7100

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Deposited on : 2010-06-21

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