Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis

Jia, Yixia; Hillgren, J. Mikael; Watson, Emma L.; Marsden, Stephen P.; Kundig, Ernst Peter

doi:10.1039/b810858g

Scientific article

English

Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis

ContributorsJia, Yixia; Hillgren, J. Mikael; Watson, Emma L.; Marsden, Stephen P.; Kundig, Ernst Peter

Published inChemical communications, no. 34, p. 4040-4042

Publication date2008

Abstract

The Pd-catalysed asymmetric intramolecular a-arylation of amide enolates containing heteroatom substituents gives chiral 3-alkoxy or 3-aminooxindoles in high yield and with enantioselectivities up to 97% ee when a new chiral N-heterocyclic carbene ligand is used.

NoteSelected as hot paper

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

JIA, Yixia et al. Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis. In: Chemical communications, 2008, n° 34, p. 4040–4042. doi: 10.1039/b810858g

Article

Identifiers

PID : unige:7029
DOI : 10.1039/b810858g
PMID : 18758619

Journal ISSN1359-7345

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Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis

The Pd-catalysed asymmetric intramolecular a-arylation of amide enolates containing heteroatom substituents gives chiral 3-alkoxy or 3-aminooxindoles in high yield and with enantioselectivities up to 97% ee when a new chiral N-heterocyclic carbene ligand is used.

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