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Voltage-Dependent Ion Channel Formation by Rigid Rod-Shaped Polyols in Planar Lipid Bilayers

Authors
Ni, Chiyou
Bezrukov, Sergey M.
Published in Bioorganic & Medicinal Chemistry Letters. 1998, vol. 8, no. 19, p. 2743-2746
Abstract In this Letter, we describe the appearance of large, voltage-dependent currents in BLM induced by rigid rodshaped polyols that function without charge and permanent dipole moment. The capacity of these symmetrical, nonpeptide models to form either short-living nanopores or small ion channels is shown to depend critically on the length of rigid-rod scaffold as well as the nature of the lateral side chains.
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SAKAI, Naomi et al. Voltage-Dependent Ion Channel Formation by Rigid Rod-Shaped Polyols in Planar Lipid Bilayers. In: Bioorganic & Medicinal Chemistry Letters, 1998, vol. 8, n° 19, p. 2743-2746. https://archive-ouverte.unige.ch/unige:7013

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Deposited on : 2010-06-18

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