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Scientific article
English

Recognition of Polarized Bilayer Membranes by p-Oligophenyl Ion Channels: From Push-Pull Rods to Push-Pull β-Barrels

Contributors

Sakai, Naomi; Matile, Stefan

Published in

Journal of the American Chemical Society, vol. 124, no. 7, p. 1184-1185

Publication date

2002

Abstract

Design, synthesis, and evaluation of 14-methoxy-84-methylsulfonyl-22,33,42,53,62,73-hexa(Gla-Leu-Lys-Leu-NH2)-p-octiphenyl (1) and 14,84-bismethoxy-22,33,42,53,62,73-hexa(Gla-Leu-Lys-Leu-NH2)-p-octiphenyl (2) are described (Gla = -OCH2CO-). Nanomolar concentrations of push-pull rod 1 are found to suffice to selectively form ion channels in polarized spherical bilayer membranes composed of egg yolk phosphatidylcholine. Exponential dependence of the ion-channel activity on membrane polarization reveals a gating charge of 0.85/channel. Independence of the activity of push-push rod 2 on membrane potential demonstrates that cell membrane recognition originates from the axial dipole in push-pull rod 1. Nonlinear concentration dependence of activity at -180 mV indicates parallel self-assembly of push-pull rod 1 into a tetrameric barrel-stave supramolecule.

UNIGE affiliation entities

Citation (ISO format)

SAKAI, Naomi, MATILE, Stefan. Recognition of Polarized Bilayer Membranes by p-Oligophenyl Ion Channels: From Push-Pull Rods to Push-Pull β-Barrels. In: Journal of the American Chemical Society, 2002, vol. 124, n° 7, p. 1184–1185. doi: 10.1021/ja017497c

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Journal ISSN

0002-7863
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Technical informations

Creation

18/06/2010 08:55:00

First validation

18/06/2010 08:55:00

Update

14/10/2025 06:58:46

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14/03/2023 15:30:37

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