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Recognition of Polarized Bilayer Membranes by p-Oligophenyl Ion Channels: From Push-Pull Rods to Push-Pull β-Barrels

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Published in Journal of the American Chemical Society. 2002, vol. 124, no. 7, p. 1184-1185
Abstract Design, synthesis, and evaluation of 14-methoxy-84-methylsulfonyl-22,33,42,53,62,73-hexa(Gla-Leu-Lys-Leu-NH2)-p-octiphenyl (1) and 14,84-bismethoxy-22,33,42,53,62,73-hexa(Gla-Leu-Lys-Leu-NH2)-p-octiphenyl (2) are described (Gla = -OCH2CO-). Nanomolar concentrations of push-pull rod 1 are found to suffice to selectively form ion channels in polarized spherical bilayer membranes composed of egg yolk phosphatidylcholine. Exponential dependence of the ion-channel activity on membrane polarization reveals a gating charge of 0.85/channel. Independence of the activity of push-push rod 2 on membrane potential demonstrates that cell membrane recognition originates from the axial dipole in push-pull rod 1. Nonlinear concentration dependence of activity at -180 mV indicates parallel self-assembly of push-pull rod 1 into a tetrameric barrel-stave supramolecule.
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SAKAI, Naomi, MATILE, Stefan. Recognition of Polarized Bilayer Membranes by p-Oligophenyl Ion Channels: From Push-Pull Rods to Push-Pull β-Barrels. In: Journal of the American Chemical Society, 2002, vol. 124, n° 7, p. 1184-1185. https://archive-ouverte.unige.ch/unige:6997

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Deposited on : 2010-06-18

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