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Title

Synthetic Multifunctional Pores with External and Internal Active Sites for Ligand Gating and Noncompetitive Blockage

Authors
Lazar, Adina N.
Coleman, Anthony W.
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Published in Journal of the American Chemical Society. 2004, vol. 126, no. 42, p. 13592-13593
Abstract Design, synthesis, and multifunctionality of p-octiphenyl ß-barrel pores with external LRL triads and internal HH dyads are described. Molecular recognition of anionic fullerenes > calixarenes > pyrenes by guanidinium arrays at the outer pore surface is shown to result in pore opening, whereas a-helix recognition within the topologically matching internal space is shown to result in noncompetitive pore blockage. This experimental evidence for multifunctionality is supported by comparison with pertinent control pores and blockers, by structural studies using FRET from p-octiphenyl donors in the pore to BODIPY acceptors in the bilayer, and by molecular mechanics simulations. Practical usefulness of ligand-gated synthetic multifunctional pores is exemplified with the continuous detection of chemical processes.
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GORTEAU, Virginie et al. Synthetic Multifunctional Pores with External and Internal Active Sites for Ligand Gating and Noncompetitive Blockage. In: Journal of the American Chemical Society, 2004, vol. 126, n° 42, p. 13592-13593. https://archive-ouverte.unige.ch/unige:6989

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Deposited on : 2010-06-18

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