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Scientific article
English

An Amphotericin B-Fluorescein Conjugate as a Powerful Probe for Biochemical Studies of the Membrane

Contributors

Zumbuehl, Andréas; Jeannerat, Damien; Martin, Scott E.; Sohrmann, Marc; Stano, Pasquale; Vigassy, Tamas; Clark, Daniel D.; Hussey, Stephen L.; Peter, Mathias; Peterson, Blake R.; Pretsch, Ernö; Walde, Peter; Carreira, Erick M.

Published in

Angewandte Chemie, vol. 43, no. 39, p. 5181-5185

Publication date

2004

Abstract

Not only skin deep: A fluorescein-amphotericin B conjugate with a new piperazine linker (see structure) was prepared and used as a probe of the biomembrane and the mechanism of action of amphotericin B both in vivo and in liposomal experiments. The amphotericin B analogue localizes at the membrane of yeast cells but is internalized by mammalian cells.

Keywords

  • Antifungal agents
  • Bioorganic chemistry
  • Biophysics
  • Fluorescent probes
  • Synthetic methods

UNIGE affiliation entities

Citation (ISO format)

ZUMBUEHL, Andréas et al. An Amphotericin B-Fluorescein Conjugate as a Powerful Probe for Biochemical Studies of the Membrane. In: Angewandte Chemie, 2004, vol. 43, n° 39, p. 5181–5185. doi: 10.1002/anie.200460489

Main files (1)

Article

Identifiers

Journal ISSN

1433-7851
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Technical informations

Creation

18/06/2010 08:54:52

First validation

18/06/2010 08:54:52

Update

14/03/2023 15:30:32

Status update

14/03/2023 15:30:32

Last indexation

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