Scientific article
English

An Amphotericin B-Fluorescein Conjugate as a Powerful Probe for Biochemical Studies of the Membrane

Published inAngewandte Chemie, vol. 43, no. 39, p. 5181-5185
Publication date2004
Abstract

Not only skin deep: A fluorescein-amphotericin B conjugate with a new piperazine linker (see structure) was prepared and used as a probe of the biomembrane and the mechanism of action of amphotericin B both in vivo and in liposomal experiments. The amphotericin B analogue localizes at the membrane of yeast cells but is internalized by mammalian cells.

Keywords
  • Antifungal agents
  • Bioorganic chemistry
  • Biophysics
  • Fluorescent probes
  • Synthetic methods
Citation (ISO format)
ZUMBUEHL, Andréas et al. An Amphotericin B-Fluorescein Conjugate as a Powerful Probe for Biochemical Studies of the Membrane. In: Angewandte Chemie, 2004, vol. 43, n° 39, p. 5181–5185. doi: 10.1002/anie.200460489
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Journal ISSN1433-7851
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