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Title

An Amphotericin B-Fluorescein Conjugate as a Powerful Probe for Biochemical Studies of the Membrane

Authors
Martin, Scott E.
Sohrmann, Marc
Stano, Pasquale
Vigassy, Tamas
Clark, Daniel D.
Hussey, Stephen L.
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Published in Angewandte Chemie: International Edition. 2004, vol. 43, no. 39, p. 5181-5185
Abstract Not only skin deep: A fluorescein-amphotericin B conjugate with a new piperazine linker (see structure) was prepared and used as a probe of the biomembrane and the mechanism of action of amphotericin B both in vivo and in liposomal experiments. The amphotericin B analogue localizes at the membrane of yeast cells but is internalized by mammalian cells.
Keywords Antifungal agentsBioorganic chemistryBiophysicsFluorescent probesSynthetic methods
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ZUMBUEHL, Andréas et al. An Amphotericin B-Fluorescein Conjugate as a Powerful Probe for Biochemical Studies of the Membrane. In: Angewandte Chemie: International Edition, 2004, vol. 43, n° 39, p. 5181-5185. https://archive-ouverte.unige.ch/unige:6978

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Deposited on : 2010-06-18

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