Scientific article
Letter
English

Rapid Access to Synthetic Lysobisphosphatidic Acids Using PIII Chemistry

Published inOrganic letters, vol. 2, no. 13, p. 1859-1861
Publication date2000
Abstract

An expeditious route to synthetic lysobisphosphatidic acid S,S-1, its enantiomer, and regioisomers is reported. Synthetic difficulties concerning lipid stability and stereochemistry are bypassed using a phosphite triester approach in combination with multiple silyl protection. Spectroscopic studies evidence that acyl group migration in S,S-1 is accelerated by nonpolar solvents and inhibited by pyridine.

Citation (ISO format)
CHEVALLIER, Julien et al. Rapid Access to Synthetic Lysobisphosphatidic Acids Using PIII Chemistry. In: Organic letters, 2000, vol. 2, n° 13, p. 1859–1861. doi: 10.1021/ol0059246
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Journal ISSN1523-7052
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