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Scientific article
Letter
English

Synthesis of (-)-Lasubine(I) via a Planar Chiral [(η6-Arene)Cr(CO)3] Complex

Published inOrganic letters, vol. 1, no. 12, p. 1997-1999
Publication date1999
Abstract

Key steps of the synthesis of the Lythraceae alkaloid (-)-lasubine(I) are the formation of an enantiopure planar chiral arylaldehyde tricarbonylchromium complex and highly diastereoselective aza-Diels-Alder cycloaddition and intramolecular radical cyclization reactions to afford a quinolizidinone intermediate. Ketone reduction, desilylation, and decomplexation yield the enantiomerically pure product.

Citation (ISO format)
RATNI, Hasane, KUNDIG, Ernst Peter. Synthesis of (-)-Lasubine(I) via a Planar Chiral [(η6-Arene)Cr(CO)3] Complex. In: Organic letters, 1999, vol. 1, n° 12, p. 1997–1999. doi: 10.1021/ol991158v
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