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Title

Kinetic Resolution of Diols and Pyridyl Alcohols by Cu(II)(borabox)-Catalyzed Acylation

Authors
Roseblade, Stephen
Köhler, Valentin
Pfaltz, Andreas
Published in Organic Letters. 2006, vol. 8, no. 9, p. 1879-1882
Abstract Boron-bridged bisoxazoline (borabox) ligands have been used in the copper(II)-catalyzed benzoylation of pyridyl alcohols and 1,2-diols. Efficient kinetic resolution of 1,2-diols was achieved using both borabox and bisoxazoline (box) ligands. Borabox ligands induced high selectivities in the benzoylation of suitable pyridyl alcohols, where they outperformed bisoxazolines. In addition, highly enantioselective Cu(II)(borabox)-catalyzed benzoylation has been used for the synthesis of both enantiomers of a pyridyl alcohol.
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PMID: 16623574
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MAZET, Clement et al. Kinetic Resolution of Diols and Pyridyl Alcohols by Cu(II)(borabox)-Catalyzed Acylation. In: Organic Letters, 2006, vol. 8, n° 9, p. 1879-1882. https://archive-ouverte.unige.ch/unige:6933

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Deposited on : 2010-06-18

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