A Novel Strategy for Bioconjugation: Synthesis and Preliminary Evaluation with Amphotericin B

Zumbuehl, Andréas; Stano, Pasquale; Sohrmann, Marc; Peter, Mathias; Walde, Peter; Carreira, Erick M.

doi:10.1039/b701953j

Scientific article

English

A Novel Strategy for Bioconjugation: Synthesis and Preliminary Evaluation with Amphotericin B

ContributorsZumbuehl, Andréas; Stano, Pasquale; Sohrmann, Marc; Peter, Mathias; Walde, Peter; Carreira, Erick M.

Published inOrganic & biomolecular chemistry, vol. 5, no. 9, p. 1339-1342

Publication date2007

Abstract

A novel linker strategy is presented based on a double reductive amination of a dialdehyde to the amine of the amphotericin B mycosamine sugar and the biological activity of a series of conjugates is compared to the native amphotericin B.

Affiliation entities

Not a UNIGE publication

Citation (ISO format)

ZUMBUEHL, Andréas et al. A Novel Strategy for Bioconjugation: Synthesis and Preliminary Evaluation with Amphotericin B. In: Organic & biomolecular chemistry, 2007, vol. 5, n° 9, p. 1339–1342. doi: 10.1039/b701953j

Article

Identifiers

PID : unige:6930
DOI : 10.1039/b701953j
PMID : 17464400

Journal ISSN1477-0520

640views

0downloads

Creation18/06/2010 08:54:25

First validation18/06/2010 08:54:25

Update14/03/2023 15:30:19

Status update14/03/2023 15:30:19

Last indexation10/06/2025 21:33:03

Archive ouverte UNIGE

A Novel Strategy for Bioconjugation: Synthesis and Preliminary Evaluation with Amphotericin B

A novel linker strategy is presented based on a double reductive amination of a dialdehyde to the amine of the amphotericin B mycosamine sugar and the biological activity of a series of conjugates is compared to the native amphotericin B.

Technical informations