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Title

A Novel Strategy for Bioconjugation: Synthesis and Preliminary Evaluation with Amphotericin B

Authors
Stano, Pasquale
Sohrmann, Marc
Peter, Mathias
Walde, Peter
Carreira, Erick M.
Published in Organic and Biomolecular Chemistry. 2007, vol. 5, no. 9, p. 1339-1342
Abstract A novel linker strategy is presented based on a double reductive amination of a dialdehyde to the amine of the amphotericin B mycosamine sugar and the biological activity of a series of conjugates is compared to the native amphotericin B.
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PMID: 17464400
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ZUMBUEHL, Andréas et al. A Novel Strategy for Bioconjugation: Synthesis and Preliminary Evaluation with Amphotericin B. In: Organic and Biomolecular Chemistry, 2007, vol. 5, n° 9, p. 1339-1342. https://archive-ouverte.unige.ch/unige:6930

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Deposited on : 2010-06-18

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