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Formation of giant amphiphiles by post-functionalization of hydrophilic protein-polymer conjugates

Authors
Mantovani, Giuseppe
Haddleton, David M.
Velonia, Kelly
Published in Journal of Materials Chemistry. 2007, vol. 17, no. 19, p. 1916-1922
Abstract A novel, generic method for the synthesis of families of tri-block protein–polymer giant amphiphiles was designed and developed. We have synthesized a hydrophilic α-maleimido poly-1-alkyne with Mn = 9.5 kDa (1H-NMR) and narrow PDi (1.15 as measured by SEC) via ATRP (Atom Transfer Radical Polymerization). This polymer was succesfully coupled to BSA to afford a hydrophilic multifunctional bioconjugate which was isolated using protein purification techniques and fully characterized. Following the post-functionalization approach, we introduced hydrophobicity to the resulting hydrophilic biohybrid by a straightforward, high yield "click"-chemistry cycloaddition step. The resulting tri-block protein–polymer amphiphiles were isolated and showed interesting aggregation patterns (TEM, confocal microscopy).
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LE DROUMAGUET, Benjamin et al. Formation of giant amphiphiles by post-functionalization of hydrophilic protein-polymer conjugates. In: Journal of Materials Chemistry, 2007, vol. 17, n° 19, p. 1916-1922. doi: 10.1039/b618079e https://archive-ouverte.unige.ch/unige:6915

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Deposited on : 2010-06-18

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