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Scientific article
English

Formation of giant amphiphiles by post-functionalization of hydrophilic protein-polymer conjugates

Contributors

Le Droumaguet, Benjamin; Mantovani, Giuseppe; Haddleton, David M.; Velonia, Kelly

Published in

Journal of Materials Chemistry, vol. 17, no. 19, p. 1916-1922

Publication date

2007

Abstract

A novel, generic method for the synthesis of families of tri-block protein–polymer giant amphiphiles was designed and developed. We have synthesized a hydrophilic α-maleimido poly-1-alkyne with Mn = 9.5 kDa (1H-NMR) and narrow PDi (1.15 as measured by SEC) via ATRP (Atom Transfer Radical Polymerization). This polymer was succesfully coupled to BSA to afford a hydrophilic multifunctional bioconjugate which was isolated using protein purification techniques and fully characterized. Following the post-functionalization approach, we introduced hydrophobicity to the resulting hydrophilic biohybrid by a straightforward, high yield "click"-chemistry cycloaddition step. The resulting tri-block protein–polymer amphiphiles were isolated and showed interesting aggregation patterns (TEM, confocal microscopy).

UNIGE affiliation entities

Citation (ISO format)

LE DROUMAGUET, Benjamin et al. Formation of giant amphiphiles by post-functionalization of hydrophilic protein-polymer conjugates. In: Journal of Materials Chemistry, 2007, vol. 17, n° 19, p. 1916–1922. doi: 10.1039/b618079e

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18/06/2010 08:54:18

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