Bulky Chiral Carbene Ligands and Their Application in the Palladium-Catalyzed Asymmetric Intramolecular α-Arylation of Amides

Kundig, Ernst Peter; Seidel, Thomas; Jia, Yixia; Bernardinelli, Gérald Hugues

doi:10.1002/anie.200703408

Scientific article

English

Bulky Chiral Carbene Ligands and Their Application in the Palladium-Catalyzed Asymmetric Intramolecular α-Arylation of Amides

ContributorsKundig, Ernst Peter; Seidel, Thomas; Jia, Yixia; Bernardinelli, Gérald Hugues

Published inAngewandte Chemie, vol. 46, no. 44, p. 8484-8487

Publication date2007

Abstract

Bring on the big cats: New, C2-symmetric bulky N-heterocyclic carbene ligands bring major improvements in the palladium-catalyzed asymmetric intramolecular α-arylation of amides to give oxindoles (see picture, dba=trans,trans-dibenzylideneacetone), which are formed in high yield and excellent enantiomeric purity.

Keywords

Asymmetric catalysis
Heterocycles
NHC ligands
Oxindoles
Palladium

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

KUNDIG, Ernst Peter et al. Bulky Chiral Carbene Ligands and Their Application in the Palladium-Catalyzed Asymmetric Intramolecular α-Arylation of Amides. In: Angewandte Chemie, 2007, vol. 46, n° 44, p. 8484–8487. doi: 10.1002/anie.200703408

Article

Identifiers

PID : unige:6900
DOI : 10.1002/anie.200703408
PMID : 17912728

Journal ISSN1433-7851

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Bulky Chiral Carbene Ligands and Their Application in the Palladium-Catalyzed Asymmetric Intramolecular α-Arylation of Amides

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