Scientific article
English

Bulky Chiral Carbene Ligands and Their Application in the Palladium-Catalyzed Asymmetric Intramolecular α-Arylation of Amides

Published inAngewandte Chemie, vol. 46, no. 44, p. 8484-8487
Publication date2007
Abstract

Bring on the big cats: New, C2-symmetric bulky N-heterocyclic carbene ligands bring major improvements in the palladium-catalyzed asymmetric intramolecular α-arylation of amides to give oxindoles (see picture, dba=trans,trans-dibenzylideneacetone), which are formed in high yield and excellent enantiomeric purity.

Keywords
  • Asymmetric catalysis
  • Heterocycles
  • NHC ligands
  • Oxindoles
  • Palladium
Citation (ISO format)
KUNDIG, Ernst Peter et al. Bulky Chiral Carbene Ligands and Their Application in the Palladium-Catalyzed Asymmetric Intramolecular α-Arylation of Amides. In: Angewandte Chemie, 2007, vol. 46, n° 44, p. 8484–8487. doi: 10.1002/anie.200703408
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Journal ISSN1433-7851
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