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Distinct regulation of salinity and genotoxic stress responses by Arabidopsis MAP kinase phosphatase 1

Ichimura, Kazuya
Mizoguchi, Tsuyoshi
Peck, Scott C.
Zhu, Tong
Wang, Xun
Shinozaki, Kazuo
Published in EMBO Journal. 2002, vol. 21, no. 23, p. 6483-93
Abstract The Arabidopsis genome contains 20 genes encoding mitogen-activated protein kinases (MAPKs), which drastically outnumbers genes for their negative regulators, MAP kinase phosphatases (MKPs) (five at most). This contrasts sharply with genomes of other eukaryotes where the number of MAPKs and MKPs is approximately equal. MKPs may therefore play an important role in signal integration in plants, through concerted regulation of several MAPKs. Our previous studies identified Arabidopsis MKP1 and showed that its deficiency in the mkp1 mutant results in plant hypersensitivity to genotoxic stress. Here, we identify a set of MAPKs that interact with MKP1, and show that the activity level of one of these, MPK6, is regulated by MKP1 in vivo. Moreover, using expression profiling, we identified a specific group of genes that probably represent targets of MKP1 regulation. Surprisingly, the identity of these genes and interacting MAPKs suggested involvement of MKP1 in salt stress responses. Indeed, mkp1 plants have increased resistance to salinity. Thus MKP1 apparently plays a pivotal role in the integration and fine-tuning of plant responses to various environmental challenges.
Keywords Arabidopsis/enzymologyCatalytic Domain/physiologyCell Cycle ProteinsConserved SequenceDual Specificity Phosphatase 1Immediate-Early Proteins/physiologyMitogen-Activated Protein Kinases/drug effects/genetics/metabolism/radiation effectsPhosphoprotein PhosphatasesProtein Phosphatase 1Protein Tyrosine Phosphatases/physiologySaline Solution, HypertonicSignal Transduction/physiologyUltraviolet Rays
PMID: 12456655
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ULM, Roman et al. Distinct regulation of salinity and genotoxic stress responses by Arabidopsis MAP kinase phosphatase 1. In: EMBO Journal, 2002, vol. 21, n° 23, p. 6483-93. doi: 10.1093/emboj/cdf646

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Deposited on : 2010-06-10

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