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Scientific article
English

Asymmetric addition of α-hetero-disubstituted aldehydes to vinyl sulfones; formation of highly functionalized tetrasubstituted carbon centres

Contributors

Quintard, Adrien; Alexakis, Alexandre

Published in

Chemical communications, vol. 46, no. 23, p. 4085-4087

Publication date

2010

Abstract

Aminal–pyrrolidine catalysed addition of α-hetero-disubstituted aldehydes to vinyl sulfones is described in high enantioselectivity (ee up to 97%). The obtained adducts can easily be converted to enantioenriched synthons as for example 2,2-dialkylepoxide. Evidence for a kinetic resolution is also observed.

UNIGE affiliation entities

Citation (ISO format)

QUINTARD, Adrien, ALEXAKIS, Alexandre. Asymmetric addition of α-hetero-disubstituted aldehydes to vinyl sulfones; formation of highly functionalized tetrasubstituted carbon centres. In: Chemical communications, 2010, vol. 46, n° 23, p. 4085–4087. doi: 10.1039/c000326c

Main files (1)

Article (Published version)

Identifiers

Additional URL for this publication

http://xlink.rsc.org/?DOI=c000326c

Journal ISSN

1359-7345
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Technical informations

Creation

05/06/2010 15:52:00

First validation

05/06/2010 15:52:00

Update

14/03/2023 15:29:39

Status update

14/03/2023 15:29:39

Last indexation

29/10/2024 14:58:37
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