Asymmetric addition of α-hetero-disubstituted aldehydes to vinyl sulfones; formation of highly functionalized tetrasubstituted carbon centres

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Title		Asymmetric addition of α-hetero-disubstituted aldehydes to vinyl sulfones; formation of highly functionalized tetrasubstituted carbon centres
Authors		Quintard, Adrien Alexakis, Alexandre
Published in		Chemical Communications. 2010, vol. 46, no. 23, p. 4085-4087
Abstract		Aminal–pyrrolidine catalysed addition of α-hetero-disubstituted aldehydes to vinyl sulfones is described in high enantioselectivity (ee up to 97%). The obtained adducts can easily be converted to enantioenriched synthons as for example 2,2-dialkylepoxide. Evidence for a kinetic resolution is also observed.
Identifiers		DOI: 10.1039/c000326c
Full text		Article (Published version) (521 Kb) - Limited access to UNIGE Other version: http://xlink.rsc.org/?DOI=c000326c
Structures		Faculté des sciences / Section de chimie et biochimie / Département de chimie organique
Citation (ISO format)		QUINTARD, Adrien, ALEXAKIS, Alexandre. Asymmetric addition of α-hetero-disubstituted aldehydes to vinyl sulfones; formation of highly functionalized tetrasubstituted carbon centres. In: Chemical Communications, 2010, vol. 46, n° 23, p. 4085-4087. doi: 10.1039/c000326c https://archive-ouverte.unige.ch/unige:6780

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Deposited on : 2010-06-07

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