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Scientific article
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Asymmetric addition of α-hetero-disubstituted aldehydes to vinyl sulfones; formation of highly functionalized tetrasubstituted carbon centres

Published inChemical communications, vol. 46, no. 23, p. 4085-4087
Publication date2010
Abstract

Aminal–pyrrolidine catalysed addition of α-hetero-disubstituted aldehydes to vinyl sulfones is described in high enantioselectivity (ee up to 97%). The obtained adducts can easily be converted to enantioenriched synthons as for example 2,2-dialkylepoxide. Evidence for a kinetic resolution is also observed.

Citation (ISO format)
QUINTARD, Adrien, ALEXAKIS, Alexandre. Asymmetric addition of α-hetero-disubstituted aldehydes to vinyl sulfones; formation of highly functionalized tetrasubstituted carbon centres. In: Chemical communications, 2010, vol. 46, n° 23, p. 4085–4087. doi: 10.1039/c000326c
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ISSN of the journal1359-7345
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Creation06/05/2010 3:52:00 PM
First validation06/05/2010 3:52:00 PM
Update time03/14/2023 3:29:39 PM
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