Asymmetric addition of α-hetero-disubstituted aldehydes to vinyl sulfones; formation of highly functionalized tetrasubstituted carbon centres

Quintard, Adrien; Alexakis, Alexandre

doi:10.1039/c000326c

Scientific article

English

Asymmetric addition of α-hetero-disubstituted aldehydes to vinyl sulfones; formation of highly functionalized tetrasubstituted carbon centres

ContributorsQuintard, Adrien; Alexakis, Alexandre

Published inChemical communications, vol. 46, no. 23, p. 4085-4087

Publication date2010

Abstract

Aminal–pyrrolidine catalysed addition of α-hetero-disubstituted aldehydes to vinyl sulfones is described in high enantioselectivity (ee up to 97%). The obtained adducts can easily be converted to enantioenriched synthons as for example 2,2-dialkylepoxide. Evidence for a kinetic resolution is also observed.

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

QUINTARD, Adrien, ALEXAKIS, Alexandre. Asymmetric addition of α-hetero-disubstituted aldehydes to vinyl sulfones; formation of highly functionalized tetrasubstituted carbon centres. In: Chemical communications, 2010, vol. 46, n° 23, p. 4085–4087. doi: 10.1039/c000326c

Article (Published version)

Identifiers

PID : unige:6780
DOI : 10.1039/c000326c

Additional URL for this publicationhttp://xlink.rsc.org/?DOI=c000326c

Journal ISSN1359-7345

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Asymmetric addition of α-hetero-disubstituted aldehydes to vinyl sulfones; formation of highly functionalized tetrasubstituted carbon centres

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