UNIGE document Scientific Article
previous document  unige:677  next document
add to browser collection
Title

Hormone replacement therapy, mammography screening and changing age-specific incidence rates of breast cancer: an ecological study comparing two European populations

Authors
Koot, V C M.
van der Heiden, M.
Schipper, M E I.
Peeters, P H M.
Peterse, J L.
show hidden authors show all authors [1 - 9]
Published in Breast Cancer Research and Treatment. 2008, vol. 107, no. 3, p. 389-95
Abstract BACKGROUND: In 2003, for the first time, US breast cancer incidence rates have fallen. Experts argue whether this is due to the reduced uptake of screening mammography or to lower use of Hormone Replacement Therapy (HRT). This study aims to disentangle the respective impact of screening and HRT on age-incidence rates and histology of breast cancer, by comparing two populations with comparably high levels of screening mammography, but with different prevalence of HRT. METHODS: We included all invasive breast cancers recorded at the Geneva cancer registry (n = 4,909) and the Netherlands Cancer Registry (n = 152,428) between 1989-2003. We compared age-specific incidence rates and trends in histological subtyping between the two populations. RESULTS: Between 1989-1991, incidence rates increased with age in both populations. In 2001-2003, women aged 60-64 years showed highest incidence rates in Geneva, while in the Netherlands incidence rates continued to increase with age. The annual increase in ductal cancer incidence was similar in the Netherlands (2.3%) and Geneva (2.5%), but the annual increase in lobular cancer was sharper in Geneva (10%) than in the Netherlands (5%). CONCLUSION: The sharp differences in age distribution and histological subtyping of breast cancer between two European populations are not attributable to screening, since both populations have a high uptake of mammography screening. Since the prevalence of HRT use is very high in Geneva and rather low in the Netherlands, HRT may explain these discrepancies. However, other etiological factors and differences in histological assessment may also have played a role.
Keywords AdultAge DistributionAgedAged 80 and overBreast Neoplasms/epidemiologyEstrogen Replacement TherapyFemaleHumansIncidenceMammographyMiddle AgedNetherlands/epidemiologySwitzerland/epidemiologyTime Factors
Identifiers
PMID: 17431760
Full text
Structures
Research group Groupe Bouchardy Magnin Christine (Registre genevois des tumeurs) (532)
Citation
(ISO format)
VERKOOIJEN, Helena et al. Hormone replacement therapy, mammography screening and changing age-specific incidence rates of breast cancer: an ecological study comparing two European populations. In: Breast Cancer Research and Treatment, 2008, vol. 107, n° 3, p. 389-95. https://archive-ouverte.unige.ch/unige:677

189 hits

8 downloads

Update

Deposited on : 2009-02-05

Export document
Format :
Citation style :