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Copper-catalyzed enantioselective 1,4-addition to α,β-unsaturated aldehydes |
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Published in | Organic letters. 2010, vol. 12, no. 9, p. 1988 - 1991 | |
Abstract | The first asymmetric Cu-catalyzed conjugate addition of dialkylzinc zinc reagents to a large scope of enals in presence of phosphoramidite, SimplePhos, or (R)-BINAP ligands with enantiomeric excesses up to 90% is reported. Moreover, ACA of Grignard reagents afforded moderate to good 1,4-regioselectivities with enantioselectivities up to 90%. | |
Identifiers | DOI: 10.1021/ol100441r | |
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Citation (ISO format) | PALAIS, Laëtitia et al. Copper-catalyzed enantioselective 1,4-addition to α,β-unsaturated aldehydes. In: Organic letters, 2010, vol. 12, n° 9, p. 1988 - 1991. doi: 10.1021/ol100441r https://archive-ouverte.unige.ch/unige:6581 |