Copper-catalyzed enantioselective 1,4-addition to α,β-unsaturated aldehydes

Palais, Laëtitia; Babel, Lucille; Quintard, Adrien; Belot, Sébastien; Alexakis, Alexandre

doi:10.1021/ol100441r

Scientific article

English

Copper-catalyzed enantioselective 1,4-addition to α,β-unsaturated aldehydes

ContributorsPalais, Laëtitia; Babel, Lucille; Quintard, Adrien; Belot, Sébastien; Alexakis, Alexandre

Published inOrganic letters, vol. 12, no. 9, p. 1988-1991

Publication date2010

Abstract

The first asymmetric Cu-catalyzed conjugate addition of dialkylzinc zinc reagents to a large scope of enals in presence of phosphoramidite, SimplePhos, or (R)-BINAP ligands with enantiomeric excesses up to 90% is reported. Moreover, ACA of Grignard reagents afforded moderate to good 1,4-regioselectivities with enantioselectivities up to 90%.

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

PALAIS, Laëtitia et al. Copper-catalyzed enantioselective 1,4-addition to α,β-unsaturated aldehydes. In: Organic letters, 2010, vol. 12, n° 9, p. 1988–1991. doi: 10.1021/ol100441r

Article (Published version)

Identifiers

PID : unige:6581
DOI : 10.1021/ol100441r

Journal ISSN1523-7052

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Copper-catalyzed enantioselective 1,4-addition to α,β-unsaturated aldehydes

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