Copper-catalyzed enantioselective 1,4-addition to α,β-unsaturated aldehydes

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Title		Copper-catalyzed enantioselective 1,4-addition to α,β-unsaturated aldehydes
Authors		Palais, Laëtitia Babel, Lucille Quintard, Adrien Belot, Sébastien Alexakis, Alexandre
Published in		Organic Letters. 2010, vol. 12, no. 9, p. 1988 - 1991
Abstract		The first asymmetric Cu-catalyzed conjugate addition of dialkylzinc zinc reagents to a large scope of enals in presence of phosphoramidite, SimplePhos, or (R)-BINAP ligands with enantiomeric excesses up to 90% is reported. Moreover, ACA of Grignard reagents afforded moderate to good 1,4-regioselectivities with enantioselectivities up to 90%.
Identifiers		DOI: 10.1021/ol100441r
Full text		Article (Published version) (274 Kb) - Limited access to UNIGE
Structures		Faculté des sciences / Section de chimie et biochimie / Département de chimie organique
Citation (ISO format)		PALAIS, Laëtitia et al. Copper-catalyzed enantioselective 1,4-addition to α,β-unsaturated aldehydes. In: Organic Letters, 2010, vol. 12, n° 9, p. 1988 - 1991. https://archive-ouverte.unige.ch/unige:6581

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