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Copper-catalyzed enantioselective 1,4-addition to α,β-unsaturated aldehydes

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Palais, Laëtitia
Babel, Lucille
Belot, Sébastien
Published in Organic Letters. 2010, vol. 12, no. 9, p. 1988 - 1991
Abstract The first asymmetric Cu-catalyzed conjugate addition of dialkylzinc zinc reagents to a large scope of enals in presence of phosphoramidite, SimplePhos, or (R)-BINAP ligands with enantiomeric excesses up to 90% is reported. Moreover, ACA of Grignard reagents afforded moderate to good 1,4-regioselectivities with enantioselectivities up to 90%.
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PALAIS, Laëtitia et al. Copper-catalyzed enantioselective 1,4-addition to α,β-unsaturated aldehydes. In: Organic Letters, 2010, vol. 12, n° 9, p. 1988 - 1991. https://archive-ouverte.unige.ch/unige:6581

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Deposited on : 2010-05-14

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