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Scientific article
English

Copper-catalyzed enantioselective 1,4-addition to α,β-unsaturated aldehydes

Published inOrganic letters, vol. 12, no. 9, p. 1988-1991
Publication date2010
Abstract

The first asymmetric Cu-catalyzed conjugate addition of dialkylzinc zinc reagents to a large scope of enals in presence of phosphoramidite, SimplePhos, or (R)-BINAP ligands with enantiomeric excesses up to 90% is reported. Moreover, ACA of Grignard reagents afforded moderate to good 1,4-regioselectivities with enantioselectivities up to 90%.

Citation (ISO format)
PALAIS, Laëtitia et al. Copper-catalyzed enantioselective 1,4-addition to α,β-unsaturated aldehydes. In: Organic letters, 2010, vol. 12, n° 9, p. 1988–1991. doi: 10.1021/ol100441r
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ISSN of the journal1523-7052
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