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Copper-free asymmetric allylic alkylation with grignard reagents

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Published in Angewandte Chemie: International Edition. 2010, vol. 49, no. 19, p. 3346-3350
Abstract Open wide and say AAA: The copper-free asymmetric allylic alkylation reaction of Grignard reagents, catalyzed by N-heterocyclic carbenes, is reported for allyl bromide derivatives. This reaction offers good enantioselectivity and good to excellent γ regioselectivity, particularly for the formation of quaternary chiral centers (see scheme; Mes=mesityl).
Keywords Allylic substitutionAsymmetric catalysisCarbene ligandsGrignard reagents
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JACKOWSKI, Olivier, ALEXAKIS, Alexandre. Copper-free asymmetric allylic alkylation with grignard reagents. In: Angewandte Chemie: International Edition, 2010, vol. 49, n° 19, p. 3346-3350. https://archive-ouverte.unige.ch/unige:6580

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Deposited on : 2010-05-14

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