Scientific article
OA Policy
English

Leader neurons in population bursts of 2D living neural networks

Published inNew journal of physics, vol. 10, no. 1
Publication date2008
Abstract

Eytan and Marom recently showed that the spontaneous burst activity of rat neuron cultures includes `first to fire' cells that consistently fire earlier than others. Here we analyze the behavior of these neurons in long term recordings of spontaneous activity of rat hippocampal and rat cortical neuron cultures from three different laboratories. We identify precursor events that may either subside (`aborted bursts') or can lead to a full-blown burst (`pre-bursts'). We find that the activation in the pre-burst typically has a first neuron (`leader'), followed by a localized response in its neighborhood. Locality is diminished in the bursts themselves. The long term dynamics of the leaders is relatively robust, evolving with a half-life of 23-34 hours. We show that the leaders carry information about the identity of the burst, as measured by the signature of the number of spikes per neuron in a burst. The number of spikes from leaders in the first few spikes of a precursor event is furthermore shown to be predictive with regard to the transition into a burst (pre-burst versus aborted burst). We conclude that the leaders play a role in the development of the bursts.

Keywords
  • Neuron
  • Neural network
  • Living neural network
  • Burst
  • Leader neuron
Citation (ISO format)
ECKMANN, Jean-Pierre et al. Leader neurons in population bursts of 2D living neural networks. In: New journal of physics, 2008, vol. 10, n° 1. doi: 10.1088/1367-2630/10/1/015011
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
Journal ISSN1367-2630
704views
621downloads

Technical informations

Creation26/04/2010 10:48:00
First validation26/04/2010 10:48:00
Update time14/03/2023 15:28:18
Status update14/03/2023 15:28:18
Last indexation29/10/2024 14:41:03
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack