Novel biphenol phosphoramidite ligands for the enantioselective copper-catalyzed conjugate addition of dialkyl zincs

Alexakis, Alexandre; Rosset, Stéphane; Allamand, Janik; March, Sebastien; Guillen, Frédéric; Benhaim, Cyril

doi:10.1055/s-2001-16791

Scientific article

English

Novel biphenol phosphoramidite ligands for the enantioselective copper-catalyzed conjugate addition of dialkyl zincs

Contributors

Alexakis, Alexandre; Rosset, Stéphane; Allamand, Janik; March, Sebastien; Guillen, Frédéric; Benhaim, Cyril

Published in

Synlett, no. 9, p. 1375-1378

Publication date

2001

Abstract

Phosphoramidite ligands, based on a chiral amine and atropoisomerically flexible biphenols, induce high enantioselectivities (ee's up to 98%) in the copper-catalyzed conjugate addition of dialkyl zinc reagents to a variety of Michael acceptors.

Keywords

161 Biphenols Synlett 01.pdf
Asymmetric catalysis
Copper
Zinc
Michael additions
Phosphorus
Atropoisomerism

UNIGE affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

ALEXAKIS, Alexandre et al. Novel biphenol phosphoramidite ligands for the enantioselective copper-catalyzed conjugate addition of dialkyl zincs. In: Synlett, 2001, n° 9, p. 1375–1378. doi: 10.1055/s-2001-16791

Identifiers

PID : unige:6318
DOI : 10.1055/s-2001-16791

Journal ISSN

0936-5214

768views

0downloads

Creation

20/04/2010 10:10:34

First validation

20/04/2010 10:10:34

Update

14/03/2023 15:28:07

Status update

14/03/2023 15:28:07

Last indexation

29/10/2024 14:39:43

Novel biphenol phosphoramidite ligands for the enantioselective copper-catalyzed conjugate addition of dialkyl zincs

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation