Blockage of Rigid-Rod β-Barrel Pores by Rigid-Rod α-Helix Mimics
|Published in||Supramolecular Chemistry. 2005, vol. 17, no. 1-2, p. 135-139|
|Abstract||We report the completion of a series of biological ß-barrel pores blocked by an agr-helix (Oomen et al., EMBO J. 2004, 23, 1257) and rigid-rod ß-barrel pores blocked by an a-helix (Sordé and Matile, J. Supramol. Chem. 2002, 2, 191) with experimental evidence for a rigid-rod ß-barrel pore blocked by a rigid-rod a-helix mimic. These presumably dimeric, shape-persistent p-oligophenyl a-helix mimics are of interest to address the functional-group density of full a-helix surfaces and to obtain insights into a-helix folding and recognition.|
|Keywords||Barrel-stave supramolecules — Lipid bilayer membranes — Molecular recognition — Self-assembly — Synthetic multifunctional pores|
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|LITVINCHUK, Svetlana, MATILE, Stefan. Blockage of Rigid-Rod β-Barrel Pores by Rigid-Rod α-Helix Mimics. In: Supramolecular Chemistry, 2005, vol. 17, n° 1-2, p. 135-139. https://archive-ouverte.unige.ch/unige:6257|