Chiroptical Rhythmicity, Part 2: Evidence for Signal Transduction by Stereoselective Ion Pair Formation at the Membrane
|Published in||Enantiomer. 1999, vol. 4, no. 2, p. 131-139|
|Abstract||The initiation mechanism of chiroptical rhythmicity, a novel chiroptical phenomenon (Ghebremariam and Matile preceding contribution), was investigated by exploring the functionality of five structural analogs of the inducing L-His ligand. Disappearnace of chiroptical rhythmicity with L-His methyl esters as well as with D-His implied that stereoselective ion pair formation between carboxylate anion of L-His bound at the membrane/water interface and ammonium cations of phosphatidylcholine is essential for signal transduction to the hydrophobic core of the membrane. It was further shown that "H" aggregation of the asymmetric septi(p-phenylene) chromophore induced by multivalent L-His (i.e., poly-L-His) exceeds the extent required for chiroptical rhythmicity by far and ultimately results in the formation of achiral herringbone lattices.|
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|GHEBREMARIAM, Bereket, MATILE, Stefan. Chiroptical Rhythmicity, Part 2: Evidence for Signal Transduction by Stereoselective Ion Pair Formation at the Membrane. In: Enantiomer, 1999, vol. 4, n° 2, p. 131-139. https://archive-ouverte.unige.ch/unige:6245|